Nanotechnology. 2019 May 10;30(19):195701. doi: 10.1088/1361-6528/ab011a. Epub 2019 Feb 22.
Silver nanoparticles were synthesized by using the white flower extract of Albizia lebbeck as a source of reducing and capping agents. A. lebbeck white flower extract and silver nanoparticles were checked for their antibacterial activity against Staphylococcus aureus, Escherichia coli, Pseudomonas aeroginosa and Ba cillus subtilis by using Mueller Hinton agar, nutrient agar and Luria Bertani agar using the well diffusion method. The synthesized silver nanoparticles did not show antibacterial activity at lower (0.1-0.4 mg ml) or higher (0.5-2.5 mg ml) concentrations against any of the four organisms on either of the media, even though silver nanoparticles have been well known to show antibacterial activity even at lower concentrations. The non-antibacterial properties of the synthesized silver nanoparticles against all four bacteria were confirmed using viability counting. With this unique non-antibacterial property of biogenous silver nanoparticles observed in this study, it can be stated that case by case evaluation of every synthesized silver nanoparticle needs to be done as there are multiple factors influencing their properties. Anticancer activity of these nanoparticles at different concentrations against A549 cancer cells did not show any significant decrease in cell viability highlighting its biocompatible nature. Thus, these silver nanoparticles can be a best suited candidate for drug delivery.
采用印度金合欢白花提取物作为还原剂和稳定剂合成了银纳米粒子。采用琼脂平板扩散法，分别用 M ueller Hinton 琼脂、营养琼脂和 Luria Bertani 琼脂检测印度金合欢白花提取物和银纳米粒子对金黄色葡萄球菌、大肠杆菌、铜绿假单胞菌和枯草芽孢杆菌的抗菌活性。在所研究的两种培养基上，即使在较低（0.1-0.4mg/ml）或较高浓度（0.5-2.5mg/ml）下，合成的银纳米粒子对这四种细菌均无抗菌活性，尽管银纳米粒子即使在较低浓度下也具有良好的抗菌活性。采用细胞活力计数法证实了合成的银纳米粒子对所有四种细菌均无抗菌特性。本研究观察到生物源银纳米粒子具有这种独特的非抗菌特性，可以说需要对每种合成的银纳米粒子进行个案评估，因为有多种因素影响其特性。这些纳米粒子在不同浓度下对 A549 癌细胞的抗癌活性没有显示出细胞活力有任何显著降低，突出了其生物相容性。因此，这些银纳米粒子可能是药物输送的最佳候选者。
