Gharpure Saee, Ankamwar Balaprasad
Bio-Inspired Materials Research Laboratory, Department of Chemistry, Savitribai Phule Pune University (Formerly University of Pune), Ganeshkhind, Pune, 411007 India.
3 Biotech. 2021 Jul;11(7):358. doi: 10.1007/s13205-021-02905-6. Epub 2021 Jun 28.
Recent COVID-19 pandemic situation caused due to the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) affected global health as well as economics. There is global attention on prevention, diagnosis as well as treatment of COVID-19 infection which would help in easing the current situation. The use of nanotechnology and nanomedicine has been considered to be promising due to its excellent potential in managing various medical issues such as viruses which is a major threat. Nanoparticles have shown great potential in various biomedical applications and can prove to be of great use in antiviral therapy, especially over other conventional antiviral agents. This review focusses on the pathophysiology of SARS-CoV-2 and the progression of the COVID-19 disease followed by currently available treatments for the same. Use of nanotechnology has been elaborated by exploiting various nanoparticles like metal and metal oxide nanoparticles, carbon-based nanoparticles, quantum dots, polymeric nanoparticles as well as lipid-based nanoparticles along with its mechanism of action against viruses which can prove to be beneficial in COVID-19 therapeutics. However, it needs to be considered that use of these nanotechnology-based approaches in COVID-19 therapeutics only aids the human immunity in fighting the infection. The main function is performed by the immune system in combatting any infection.
最近由新型严重急性呼吸综合征冠状病毒2(SARS-CoV-2)引发的COVID-19大流行局势对全球健康和经济都造成了影响。全球都在关注COVID-19感染的预防、诊断和治疗,这将有助于缓解当前的局势。由于纳米技术和纳米医学在处理各种医学问题(如作为主要威胁的病毒)方面具有出色的潜力,因此被认为很有前景。纳米颗粒在各种生物医学应用中已显示出巨大潜力,并且在抗病毒治疗中可能比其他传统抗病毒药物更有用。本综述重点关注SARS-CoV-2的病理生理学和COVID-19疾病的进展,以及目前针对该疾病的可用治疗方法。通过利用各种纳米颗粒,如金属和金属氧化物纳米颗粒、碳基纳米颗粒、量子点、聚合物纳米颗粒以及脂质基纳米颗粒,阐述了纳米技术的应用及其对病毒的作用机制,这在COVID-19治疗中可能是有益的。然而,需要考虑的是,在COVID-19治疗中使用这些基于纳米技术的方法仅有助于人体免疫力对抗感染。主要功能是由免疫系统来对抗任何感染。