a Department of Virology, Division of Medicine , Imperial College London , London , UK.
b PAPRSB Institute of Health Sciences , Universiti Brunei Darussalam , Bandar Seri Begawan , Brunei Darussalam.
Autophagy. 2019 May;15(5):917-918. doi: 10.1080/15548627.2019.1580513. Epub 2019 Feb 22.
Recent studies have suggested a role for TBK1 in mediating inflammation through macroautophagy/autophagy. While its function in inducing interferon production in response to viral infection has been extensively studied, its role in antiviral autophagy is only beginning to be appreciated. Herein we discuss the role of this multifunctional protein in both antiviral IFN production and in cytoprotective autophagy during HSV-1 infection. Lastly, we highlight the potential implication of TBK1 in the management of inflammation through autophagy, particularly within the central nervous system.
最近的研究表明，TBK1 在通过巨自噬/自噬介导炎症中发挥作用。虽然它在病毒感染引起干扰素产生中的作用已被广泛研究，但它在抗病毒自噬中的作用才刚刚开始被认识。本文讨论了这种多功能蛋白在 HSV-1 感染过程中对抗病毒 IFN 产生和细胞保护自噬的作用。最后，我们强调了 TBK1 通过自噬在炎症管理中的潜在意义，特别是在中枢神经系统中。
