Department of Medicine, University of California San Diego, La Jolla, CA, United States.
Department of Pharmacology, University of California San Diego, La Jolla, CA, United States.
Front Immunol. 2020 Oct 20;11:592949. doi: 10.3389/fimmu.2020.592949. eCollection 2020.
Adipocytes and adipose tissue play critical roles in the regulation of metabolic homeostasis. In obesity and obesity-associated metabolic diseases, immune cells infiltrate into adipose tissues. Interaction between adipocytes and immune cells re-shapes both metabolic and immune properties of adipose tissue and dramatically changes metabolic set points. Both the expression and activity of the non-canonical IKK family member TBK1 are induced in adipose tissues during diet-induced obesity. TBK1 plays important roles in the regulation of both metabolism and inflammation in adipose tissue and thus affects glucose and energy metabolism. Here we review the regulation and functions of TBK1 and the molecular mechanisms by which TBK1 regulates both metabolism and inflammation in adipose tissue. Finally, we discuss the potential of a TBK1/IKK inhibitor as a new therapy for metabolic diseases.
脂肪细胞和脂肪组织在代谢稳态的调节中起着关键作用。在肥胖和肥胖相关的代谢性疾病中，免疫细胞浸润到脂肪组织中。脂肪细胞和免疫细胞之间的相互作用重塑了脂肪组织的代谢和免疫特性，并显著改变了代谢平衡点。在饮食诱导的肥胖期间，非经典 IKK 家族成员 TBK1 的表达和活性在脂肪组织中被诱导。TBK1 在调节脂肪组织的代谢和炎症中发挥重要作用，从而影响葡萄糖和能量代谢。在这里，我们综述了 TBK1 的调节和功能，以及 TBK1 调节脂肪组织代谢和炎症的分子机制。最后，我们讨论了 TBK1/IKK 抑制剂作为治疗代谢性疾病的新疗法的潜力。
