尼日利亚奥贡博索博温大学教学医院孕妇中的人乳头瘤病毒

Human papillomavirus in pregnant women at Bowen University Teaching Hospital, Ogbomoso, Nigeria.

作者信息

Elukunbi Awoyelu Hilda, Kolawole Elijah Oladipo, Kola Julius Oloke, Afolabi Yetunde O

机构信息

a Department of Pure and Applied Biology (Microbiology/Virology Unit) , Ladoke Akintola University of Technology , Ogbomoso , Nigeria.

b Obstetrics and Gynaecology, College of Medicine , University of Ibadan , Ibadan , Nigeria.

出版信息

J Immunoassay Immunochem. 2019;40(3):283-288. doi: 10.1080/15321819.2019.1583110. Epub 2019 Feb 22.

DOI:10.1080/15321819.2019.1583110

PMID:30794040

Abstract

BACKGROUND

Trans-placental transmission of human papillomavirus infection during pregnancy and burden of cervical cancer is increasing in Nigeria. However, studies on the prevalence of HPV among pregnant women are limited in Ogbomoso.

MATERIALS AND METHODS

A total of 93 pregnant women attending the antenatal clinic of Bowen University Teaching hospital in the age range 20-45 years consented for the study. All sera were tested for the presence of IgM antibodies against HPV using a third generation Enzyme-Linked Immunosorbent Assay. Chi-square test was used to assess the association between the socio-demographic variables and HPV status. Statistical significance was set at P ≤ 0.05.

RESULTS

The overall seroprevalence of HPV was 5.38% (5/93). The mean age of the study participants was 30.62 ± 5.03 years. The highest prevalence was recorded among the age group 26-35 (6.3%; 4/64) years while the least was recorded among the age group 20-25 (6.7%; 1/15) years. None of the socio-demographic characteristics and potential risk factor considered had statistically significant association with HPV infection (P ˃ 0.05).

CONCLUSION

Awareness and screening of pregnant women should be strengthened among health stakeholders for proper management.

摘要

背景

在尼日利亚，孕期人乳头瘤病毒感染的胎盘传播及宫颈癌负担正在增加。然而，奥贡莫索地区关于孕妇中人乳头瘤病毒流行情况的研究有限。

材料与方法

共有93名年龄在20 - 45岁之间、前往鲍恩大学教学医院产前门诊就诊的孕妇同意参与本研究。使用第三代酶联免疫吸附测定法检测所有血清中抗人乳头瘤病毒IgM抗体的存在情况。采用卡方检验评估社会人口统计学变量与感染人乳头瘤病毒状态之间的关联。设定统计学显著性水平为P≤0.05。

结果

人乳头瘤病毒的总体血清阳性率为5.38%（5/93）。研究参与者的平均年龄为30.62±5.03岁。26 - 35岁年龄组的患病率最高（6.3%；即4/64），而20 - 25岁年龄组的患病率最低（6.7%；即1/15）。所考虑的社会人口统计学特征和潜在危险因素均与人乳头瘤病毒感染无统计学显著关联（P＞0.05）。