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β分布比率可信区间的计算方法及其在第二瘟疫流行期间死亡相对风险中的应用。

Methods for calculating credible intervals for ratios of beta distributions with application to relative risks of death during the second plague pandemic.

机构信息

Emergency Response Department, Public Health England, Porton Down, Salisbury, Wiltshire, United Kingdom.

Historic England, Swindon, United Kingdom.

出版信息

PLoS One. 2019 Feb 22;14(2):e0211633. doi: 10.1371/journal.pone.0211633. eCollection 2019.

Abstract

Employing historical records we are able to estimate the risk of premature death during the second plague pandemic, and identify the Black Death and pestis secunda epidemics. We show a novel method of calculating Bayesian credible intervals for a ratio of beta distributed random variables and use this to quantify uncertainty of relative risk estimates for these two epidemics which we consider in a 2 × 2 contingency table framework.

摘要

利用历史记录,我们能够估计第二次鼠疫大流行期间的过早死亡风险,并确定黑死病和第二次鼠疫流行。我们展示了一种计算β分布随机变量比的贝叶斯可信区间的新方法,并将其用于量化这两种流行病的相对风险估计的不确定性,我们在 2×2 列联表框架中考虑了这些流行病。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/667d/6386284/2101f68a8171/pone.0211633.g001.jpg

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