Mazzuoli G F, Passeri M, Gennari C, Minisola S, Antonelli R, Valtorta C, Palummeri E, Cervellin G F, Gonnelli S, Francini G
Calcif Tissue Int. 1986 Jan;38(1):3-8. doi: 10.1007/BF02556587.
In this paper we present the results of a 12-month double-blind clinical multicenter study assessing the effects of synthetic salmon calcitonin (CT) administration in a group of white postmenopausal osteoporotic women. Treated patients were given 100 MRC units of synthetic salmon CT injected i.m. in the morning every other day. Control patients received a placebo injection. All patients received 500 mg of elementary calcium p.o., b.i.d. Bone mineral content (BMC) was measured at the extreme distal radius of the nondominant arm by a dual photon bone densitometer which utilizes two radionuclides, 241Am and 125I, with energies of about 60 keV and 30 keV respectively. Biochemical parameters of calcium-phosphorus metabolism were also measured. After 12 months of treatment a significant mean increment of BMC and nondialyzable OHPr/creatinine values and a significant decrease of total OHPr/creatinine values were observed in the treated group, while controls showed a significant decrease in BMC values. These results, together with the observation that in some patients the decrease in total OHPr/creatinine values was not accompanied by an increment of BMC, show that long-term salmon CT treatment may be of benefit in postmenopausal osteoporosis and that the effects of CT on bone mass may be due not only to the inhibition of bone resorption but also to the stimulation of bone formation.
在本文中，我们展示了一项为期12个月的双盲临床多中心研究的结果，该研究评估了合成鲑鱼降钙素（CT）给药对一组绝经后骨质疏松白人女性的影响。接受治疗的患者每隔一天在早上接受100 MRC单位的合成鲑鱼CT肌肉注射。对照患者接受安慰剂注射。所有患者口服500毫克元素钙，每日两次。使用双光子骨密度仪在非优势臂的桡骨远端测量骨矿物质含量（BMC），该仪器利用两种放射性核素，即241Am和125I，能量分别约为60 keV和30 keV。还测量了钙磷代谢的生化参数。治疗12个月后，治疗组观察到BMC和非透析性OHPr/肌酐值显著平均增加，总OHPr/肌酐值显著降低，而对照组BMC值显著降低。这些结果，以及在一些患者中总OHPr/肌酐值降低并未伴随BMC增加的观察结果，表明长期鲑鱼CT治疗可能对绝经后骨质疏松有益，并且CT对骨量的影响可能不仅归因于对骨吸收的抑制，还归因于对骨形成的刺激。
