Milhaud G, Talbot J N, Coutris G
Biomedicine. 1975 May;22(3):223-32.
The efficacy of long term treatment of senile osteoporosis by low doses of calcitonin was established using five parameters of calcium kinetics and a quantitative pain scale. Under treatment the calcium balance improved, due predominantly to a decrease in bone resorption associated with an increase in bone accretion and intestinal absorption of calcium. In addition, the hormone had a marked analgesic effect, which increased with the length of the treatment. Principal components analysis enables to establish the value of a therapeutic agent for the management of a progressive disease with period of regression like osteoporosis, for which the eficacy of previously advocated treatments had never been proven.
通过钙动力学的五个参数和定量疼痛量表确定了低剂量降钙素长期治疗老年性骨质疏松症的疗效。在治疗过程中，钙平衡得到改善，这主要归因于骨吸收减少，同时伴有骨量增加和肠道钙吸收增加。此外，该激素具有显著的镇痛作用，且随着治疗时间的延长而增强。主成分分析能够确定一种治疗药物对于像骨质疏松症这种具有病情缓解期的进行性疾病的治疗价值，而之前所倡导的治疗方法的疗效从未得到证实。
