Der p 2 预防性变应原免疫治疗通过调节肺部 GM-CSF 预防小鼠哮喘。
Prophylactic allergen immunotherapy with Der p 2 prevents murine asthma by regulating lung GM-CSF.
机构信息
Laboratory of Immunoregulation and Mucosal Immunology, VIB Center for Inflammation Research, Ghent, Belgium; Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium.
Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
出版信息
J Allergy Clin Immunol. 2019 Jun;143(6):2307-2311.e5. doi: 10.1016/j.jaci.2019.02.007. Epub 2019 Feb 20.
Abstract
This mouse study demonstrates that repetitive inhalation of a single major house dust mite (HDM) allergen prevents HDM-induced allergic asthma development through suppressing the function of lung dendritic cells, thus providing an alternative to classical allergen-specific immunotherapy.
摘要
这项小鼠研究表明，通过抑制肺树突状细胞的功能，重复吸入单一主要屋尘螨（HDM）过敏原可预防 HDM 诱导的过敏性哮喘的发生，从而为经典的过敏原特异性免疫疗法提供了一种替代方法。
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Allergen immunotherapy for allergic asthma: A systematic review and meta-analysis.变应原免疫疗法治疗变应性哮喘：系统评价和荟萃分析。
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Interleukin-21-Producing CD4(+) T Cells Promote Type 2 Immunity to House Dust Mites.白细胞介素 21 产生的 CD4(+)T 细胞促进对屋尘螨的 2 型免疫。
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Long-term tolerance after allergen immunotherapy is accompanied by selective persistence of blocking antibodies.过敏原免疫治疗后的长期耐受性伴随着阻断抗体的选择性持续存在。
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House dust mite allergen induces asthma via Toll-like receptor 4 triggering of airway structural cells.屋尘螨变应原通过Toll样受体4触发气道结构细胞诱发哮喘。
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Modified Th2 responses at high-dose exposures to allergen: using an occupational model.高剂量暴露于变应原时Th2反应的改变：采用职业模型
Am J Respir Crit Care Med. 2006 Jul 1;174(1):21-5. doi: 10.1164/rccm.200506-964OC. Epub 2006 Apr 7.
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Early allergen exposure, skin prick responses, and atopic wheeze at age 5 in English children: a cohort study.英国儿童5岁时的早期过敏原暴露、皮肤点刺反应和特应性喘息：一项队列研究
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Chronic exposure to innocuous antigen in sensitized mice leads to suppressed airway eosinophilia that is reversed by granulocyte macrophage colony-stimulating factor.在致敏小鼠中长期暴露于无害抗原会导致气道嗜酸性粒细胞增多受到抑制，而粒细胞巨噬细胞集落刺激因子可逆转这种抑制作用。
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