Yanai Y, Shibasaki T, Kohno N, Mitsui T, Nakajima H
Eur Neurol. 1986;25(1):19-25. doi: 10.1159/000115981.
The concentrations of aliphatic amino acids (glycine, serine, valine, threonine, alanine, leucine, isoleucine) in lumbar cerebrospinal fluid from patients with consciousness disturbances and normal controls were measured. Thyrotropin-releasing hormone (TRH) was administered to patients and the changes of levels of consciousness and amino acid concentrations were followed before and after TRH administration. The concentrations of glycine and serine from patients were significantly higher than those from controls; they returned to the control values with improvement of consciousness disturbances. The influence of TRH upon these amino acid concentrations was not observed. These results suggest that within the central nervous system, an alteration of the level of consciousness is associated with a distortion of glycine and serine metabolism and that TRH itself has no influence upon these amino acid concentrations.
测量了意识障碍患者和正常对照者腰椎脑脊液中脂肪族氨基酸（甘氨酸、丝氨酸、缬氨酸、苏氨酸、丙氨酸、亮氨酸、异亮氨酸）的浓度。对患者给予促甲状腺激素释放激素（TRH），并观察TRH给药前后意识水平和氨基酸浓度的变化。患者的甘氨酸和丝氨酸浓度显著高于对照组；随着意识障碍的改善，它们恢复到对照值。未观察到TRH对这些氨基酸浓度的影响。这些结果表明，在中枢神经系统内，意识水平的改变与甘氨酸和丝氨酸代谢的紊乱有关，并且TRH本身对这些氨基酸浓度没有影响。
