Kelly Michael P, Kallen Michael A, Shaffrey Christopher I, Smith Justin S, Burton Douglas C, Ames Christopher P, Lafage Virginie, Schwab Frank J, Kim Han Jo, Klineberg Eric O, Bess Shay
1Department of Orthopedic Surgery, Washington University School of Medicine, St. Louis, Missouri.
2Northwestern University, Feinberg School of Medicine, Chicago, Illinois.
J Neurosurg Spine. 2019 Feb 22;30(6):801-806. doi: 10.3171/2018.11.SPINE181014. Print 2019 Jun 1.
After using PROsetta Stone crosswalk tables to calculate Patient-Reported Outcomes Measurement Information System (PROMIS) Physical Function (PF) and Pain Interference (PI) scores, the authors sought to examine 1) correlations with Scoliosis Research Society-22r (SRS-22r) scores, 2) responsiveness to change, and 3) the relationship between baseline scores and 2-year follow-up scores in adult spinal deformity (ASD).
PROsetta Stone crosswalk tables were used to converted SF-36 scores to PROMIS scores for pain and physical function in a cohort of ASD patients with 2-year follow-up. Spearman correlations were used to evaluate the relationship of PROMIS scores with SRS-22r scores. Effect size (ES) and adjusted standardized response mean (aSRM) were used to assess responsiveness to change. Linear regression was used to evaluate the association between baseline scores and 2-year follow-up scores.
In total, 425 (425/625, 68%) patients met inclusion criteria. Strong correlations (all |r| > 0.7, p < 0.001) were found between baseline and 2-year PROMIS values and corresponding SRS-22r domain scores. PROMIS-PI showed a large ES (1.09) and aSRM (0.88), indicating good responsiveness to change. PROMIS-PF showed a moderate ES (0.52) and moderate aSRM (0.69), indicating a moderate responsiveness to change. Patients with greater baseline pain complaints were associated with greater pain improvement at 2 years for both SRS-22r Pain (B = 0.39, p < 0.001) and PROMIS-PI (B = 0.45, p < 0.001). Higher functional scores at baseline were associated with greater average improvements in both SRS-22r Activity (B = 0.62, p < 0.001) and PROMIS-PF (B = 0.40, p < 0.001).
The authors found strong correlations between the SRS-22r Pain and Activity domains with corresponding PROMIS-PI and -PF scores. Pain measurements showed similar and strong ES and aSRM while the function measurements showed similar, moderate ES and aSRM at 2-year follow-up. These data support further exploration of the use of PROMIS-computer adaptive test instruments in ASD.
在使用PROsetta Stone交叉对照表计算患者报告结局测量信息系统（PROMIS）身体功能（PF）和疼痛干扰（PI）评分后，作者试图检验：1）与脊柱侧弯研究学会22r（SRS - 22r）评分的相关性；2）对变化的反应性；3）成人脊柱畸形（ASD）患者基线评分与2年随访评分之间的关系。
在一组有2年随访的ASD患者中，使用PROsetta Stone交叉对照表将SF - 36评分转换为PROMIS疼痛和身体功能评分。采用Spearman相关性分析评估PROMIS评分与SRS - 22r评分的关系。效应量（ES）和调整后的标准化反应均值（aSRM）用于评估对变化的反应性。采用线性回归评估基线评分与2年随访评分之间的关联。
共有425例（425/625，68%）患者符合纳入标准。在基线和2年的PROMIS值与相应的SRS - 22r领域评分之间发现了强相关性（所有|r|>0.7，p<0.001）。PROMIS - PI显示出较大的ES（1.09）和aSRM（0.88），表明对变化有良好的反应性。PROMIS - PF显示出中等的ES（0.52）和中等的aSRM（0.69），表明对变化有中等的反应性。对于SRS - 22r疼痛（B = 0.39，p<0.001）和PROMIS - PI（B = 0.45，p<0.001），基线疼痛主诉较多的患者在2年时疼痛改善更大。基线时较高的功能评分与SRS - 22r活动（B = 0.62，p<0.001）和PROMIS - PF（B = 0.40，p<0.001）的更大平均改善相关。
作者发现SRS - 22r疼痛和活动领域与相应的PROMIS - PI和 - PF评分之间存在强相关性。在2年随访时，疼痛测量显示出相似且较大的ES和aSRM，而功能测量显示出相似的中等ES和aSRM。这些数据支持进一步探索在ASD中使用PROMIS计算机自适应测试工具。
