J Am Dent Assoc. 2019 Apr;150(4S):S38-S46. doi: 10.1016/j.adaj.2019.01.002.
This article highlights a stabilized stannous fluoride (SnF) dentifrice that, in addition to being efficacious against caries, gingivitis, and dentin hypersensitivity, demonstrates high-performing stain prevention and removal efficacy.
An in vitro stain prevention model evaluated the efficacy of Colgate Total containing 0.454% SnF and 1% zinc phosphate compared with Crest Pro-Health Whitening Power (The Procter & Gamble Company) and a nonabrasive SnF gel. L*, a*, and b* values were measured to assess whiteness comparing untreated and stained teeth, and with statistical analysis. A stain removal clinical study was conducted as a randomized, double-blind, 2-cell, parallel-group design using Colgate Total and nonwhitening regular fluoride toothpaste. Participants were instructed to brush twice daily for 6 weeks and were examined for Lobene Composite Stain Index scores, with statistical analysis used at a significance of P < .001.
In an in vitro stain prevention study, Colgate Total performed 26% and 35% better than a competitor paste and nonabrasive SnF gel, respectively. In a clinical study, Colgate Total use showed statistically significant extrinsic tooth stain reductions by 17.5% (3 weeks) and 27.8% (6 weeks) relative to regular fluoride toothpaste. No adverse effects were reported.
The results indicate that the stabilized Colgate Total performed statistically better than other SnF pastes in an in vitro study, and statistically better than a regular fluoride toothpaste in a clinical study.
Colgate Total offers an SnF-based therapeutic dentifrice with notable performance in stain prevention and removal.
本文重点介绍了一种稳定的氟化亚锡（SnF）牙膏，除了对龋齿、牙龈炎和牙本质过敏有效外，还具有出色的预防和去除污渍的功效。
一项体外防污模型评估了 Colgate Total 牙膏（含 0.454%SnF 和 1%磷酸锌）与 Crest Pro-Health Whitening Power（宝洁公司）和非研磨性 SnF 凝胶相比的功效。通过测量 L*、a和 b值，评估未处理和染色牙齿的白度，并进行统计分析。采用随机、双盲、2 组、平行分组设计，进行了一项去除污渍的临床研究，使用 Colgate Total 和非美白常规氟化物牙膏。参与者被指示每天刷牙两次，持续 6 周，并使用 Lobene 复合污渍指数评分进行检查，统计分析的显著性水平为 P<.001。
在体外防污研究中，Colgate Total 分别比竞争牙膏和非研磨性 SnF 凝胶好 26%和 35%。在一项临床研究中，Colgate Total 的使用在 3 周和 6 周时相对于常规氟化物牙膏分别显示出统计学上显著的外源性牙齿污渍减少 17.5%和 27.8%。没有报告不良反应。
结果表明，在体外研究中，稳定的 Colgate Total 比其他 SnF 牙膏表现出统计学上的优越性，在临床研究中比常规氟化物牙膏表现出统计学上的优越性。
Colgate Total 提供了一种基于 SnF 的治疗性牙膏，在预防和去除污渍方面表现出色。
