Szechtman H, Caggiula A R, Wulkan D
Brain Res. 1978 Jul 21;150(3):569-95. doi: 10.1016/0006-8993(78)90821-1.
Knife cuts aimed at severing either the medial-lateral or dorsal fiber connections of the medial preoptic-anterior hypothalamus (MPOAH) produced two clearly distinguishable patterns of copulatory deficits in male rats. On the other hand, transverse cuts, which were designed to destroy longitudinal connections on either the anterior or posterior end of the MPOAH, did not affect sexual behavior. Males with sagittal cuts exhibited deficits primarily in the initiation of copulation. In contrast, those with dorsal cuts showed alterations primarily in the execution of copulatory behavior. Combined behavioral and anatomical evidence was interpreted as suggesting that the MOPAH has at least two regulatory functions related to sex behavior: (1) it is involved in the mediation of the initiation of copulation through its lateral connections with the medial forebrain bundle, and (2) it influences the achievement of ejaculation and the subsequent refractory period through its dorsal connections with the amygdala and the hippocampus.
旨在切断内侧视前区 - 下丘脑前部（MPOAH）内侧 - 外侧或背侧纤维连接的刀切手术，在雄性大鼠中产生了两种明显可区分的交配缺陷模式。另一方面，旨在破坏MPOAH前端或后端纵向连接的横向切口，并未影响性行为。矢状切口的雄性大鼠主要在交配起始方面表现出缺陷。相比之下，背侧切口的大鼠主要在交配行为的执行方面出现改变。行为学和解剖学的综合证据被解释为表明MPOAH至少具有两种与性行为相关的调节功能：（1）它通过与内侧前脑束的外侧连接参与交配起始的介导，（2）它通过与杏仁核和海马体的背侧连接影响射精的实现和随后的不应期。
