Miceli M O, Fleming A S, Malsbury C W
Behav Brain Res. 1983 Sep;9(3):337-60. doi: 10.1016/0166-4328(83)90137-7.
Parasagittal knife cuts along the medial preoptic area-medial anterior hypothalamus were placed at either the medial (near lateral or NL cuts) or lateral (far lateral or FL cuts) border o the medial forebrain bundle in separate groups of virgin (Experiment 1) and postparturient (Experiment 2) rats. FL cuts were placed so as to spare preoptic-hypothalamic efferent connections with the medial forebrain bundle. NL and FL knife cuts were equally effective in preventing the induction of maternal behaviour produced by repeated exposure of virgin rats to foster pups. Both types of cuts also reduced nest building in virgins. In postparturient rats, NL and FL cuts both abolished pup retrievaL and reduced nursing behaviour. However, only NL cuts disrupted lactation and nest building. NL cuts also produced chronic hyperthermia. The deficits in maternal behaviour and nest building may be independent of this hyperthermia, as shaving the fur in animals with NL cuts reduced body temperatures to control levels but did not restore these behaviours. These findings indicate that while preoptic/hypothalamic connections through the medial forebrain bundle are important for nest building and possibly lactation, other lateral connections must also be important for pup retrieval and nursing behaviour. The identity of these connections remains to be determined.
在未生育（实验1）和产后（实验2）的大鼠分组中，沿视前内侧区 - 下丘脑前内侧进行矢状旁刀切割，分别在内侧（靠近外侧或NL切割）或外侧（远离外侧或FL切割）边缘的内侧前脑束处进行。FL切割的位置设计为保留视前 - 下丘脑与内侧前脑束的传出连接。NL和FL刀切割在防止未生育大鼠反复接触寄养幼崽所诱导的母性行为方面同样有效。两种类型的切割也减少了未生育大鼠的做窝行为。在产后大鼠中，NL和FL切割均消除了幼崽取回行为并减少了哺育行为。然而，只有NL切割扰乱了泌乳和做窝行为。NL切割还导致慢性体温过高。母性行为和做窝行为的缺陷可能与这种体温过高无关，因为给NL切割的动物剃毛可将体温降至对照水平，但并未恢复这些行为。这些发现表明，虽然通过内侧前脑束的视前/下丘脑连接对做窝行为以及可能对泌乳很重要，但其他外侧连接对幼崽取回和哺育行为也一定很重要。这些连接的具体情况仍有待确定。
