Lutjen P J, Findlay J K, Trounson A O, Leeton J F, Chan L K
J Clin Endocrinol Metab. 1986 Feb;62(2):419-23. doi: 10.1210/jcem-62-2-419.
A sequential regimen of steroid replacement of oral estradiol valerate and progesterone (P) by intravaginal suppository was developed for women with premature ovarian failure or ovarian agenesis. The regimen, based on a 28-day cycle, resulted in peripheral plasma concentrations of estradiol and P within the normal range of the menstrual cycle and endometrial differentiation consistent with the normal secretory phase. Pregnancy has now been successfully established in four patients following this regimen of steroid treatment and transfer of donated embryos. Plasma concentrations of LH were within the normal range by the end of the first cycle of treatment with exogenous steroids. However, plasma FSH remained above the normal range, even during the third treatment cycle, consistent with the necessity of a gonadal feedback factor (inhibin?) other than estradiol and P for maintaining FSH in the normal range. Although 7/8 patients had a surge of LH at midcycle, only 3/8 patients had concomitant FSH surges, supporting a role for progesterone in facilitating the midcycle FSH surge.
为卵巢早衰或卵巢发育不全的女性研发了一种序贯激素替代疗法，即口服戊酸雌二醇，并用阴道栓剂补充孕激素（P）。该疗法以28天为一个周期，可使外周血中雌二醇和P的浓度维持在月经周期的正常范围内，子宫内膜分化与正常分泌期相符。在接受这种激素治疗方案并移植捐赠胚胎后，已有4名患者成功受孕。在外源性类固醇治疗的第一个周期结束时，血浆促黄体生成素（LH）浓度处于正常范围内。然而，即使在第三个治疗周期，血浆促卵泡生成素（FSH）仍高于正常范围，这表明除了雌二醇和P之外，还需要一种性腺反馈因子（抑制素？）来将FSH维持在正常范围内。虽然8名患者中有7名在月经周期中期出现LH高峰，但只有3名患者同时出现FSH高峰，这支持了孕激素在促进月经周期中期FSH高峰方面的作用。
