Leeton J, Rogers P, Cameron I, Caro C, Healy D
Monash University Department of Obstetrics and Gynaecology Monash Medical Centre, Clayton, Victoria, Australia.
J In Vitro Fert Embryo Transf. 1989 Aug;6(4):232-5. doi: 10.1007/BF01132871.
This study was undertaken to evaluate the effectiveness of a new, constant low-dose, variable-length estrogen replacement therapy in preparing the endometrium of women suffering premature ovarian failure for embryo implantation. Five of 10 patients receiving the new regime became pregnant following a total of 14 embryo transfers. This study proves the efficacy of low-dosage variable-length estrogen replacement therapy for preparing the endometrium for embryo implantation in patients suffering premature ovarian failure. These studies confirm earlier observations that sequentially increasing doses of estrogen during the follicular phase are unnecessary for implantation and that the length of the follicular phase within certain undefined limits is not critical. A second important observation arising from this study concerns the relative effectiveness of the route of administration of progesterone. Five of seven patients became pregnant after receiving vaginal pessaries, compared to none of seven following intramuscular injections.
本研究旨在评估一种新的、持续低剂量、可变长度的雌激素替代疗法在为卵巢早衰女性准备子宫内膜以进行胚胎植入方面的有效性。接受新方案治疗的10名患者中有5名在总共14次胚胎移植后怀孕。本研究证明了低剂量可变长度雌激素替代疗法在为卵巢早衰患者准备子宫内膜以进行胚胎植入方面的疗效。这些研究证实了早期的观察结果，即在卵泡期依次增加雌激素剂量对于植入并非必要，并且在某些未明确界定的范围内卵泡期的长度并不关键。本研究得出的第二个重要观察结果涉及孕酮给药途径的相对有效性。接受阴道栓剂治疗的7名患者中有5名怀孕，而接受肌肉注射的7名患者中无人怀孕。
