Younis J S, Mordel N, Ligovetzky G, Lewin A, Schenker J G, Laufer N
Department of Obstetrics & Gynecology, Hadassah University Hospital, Ein-Karem, Jerusalem, Israel.
J In Vitro Fert Embryo Transf. 1991 Apr;8(2):84-8. doi: 10.1007/BF01138660.
Stretching the duration of an artificial follicular phase in an oocyte donation program facilitates greatly the synchronization between the donor and the recipient. In order to investigate the limits of such a prolonged endometrial preparation, 18 patients with ovarian failure were studied during 20 treatment cycles. These patients were prospectively and randomly divided into three groups (A, B, and C in eight, six, and six cycles respectively). All groups were treated with oral estradiol and estriol (at a 2:1 ratio), 4 mg/day for 21, 28, and 35 days, respectively. At this stage 50 mg/day of intramuscular progesterone was added for additional 7 days. Endometrial adequacy was evaluated by late follicular and midluteal endometrial biopsies. During treatment no patient suffered from breakthrough bleeding. The mean estradiol and progesterone levels during the follicular and luteal phases did not differ significantly between groups. All late follicular biopsies showed a normal proliferative endometrium with no signs of glandular cystic hyperplasia. The midluteal biopsy showed a secretory endometrium adequate for 18.6 +/- 1.8, 21.8 +/- 1.8, and 18.6 +/- 1.5 days in groups A, B, and C, respectively, with no significant glandular-stromal disparity. We conclude that an artificial prolonged follicular phase does not seem to affect adversely the endometrial preparation in an oocyte donation program.
在卵母细胞捐赠计划中延长人工卵泡期的时长，极大地促进了供体和受体之间的同步。为了研究这种延长的子宫内膜准备的限度，在20个治疗周期中对18例卵巢功能衰竭患者进行了研究。这些患者被前瞻性地随机分为三组（A组、B组和C组，分别为8个周期、6个周期和6个周期）。所有组均接受口服雌二醇和雌三醇（比例为2:1）治疗，分别为4毫克/天，持续21天、28天和35天。在此阶段，额外添加50毫克/天的肌内注射黄体酮，持续7天。通过卵泡晚期和黄体中期子宫内膜活检评估子宫内膜的适宜性。治疗期间没有患者出现突破性出血。卵泡期和黄体期的平均雌二醇和黄体酮水平在各组之间没有显著差异。所有卵泡晚期活检均显示子宫内膜呈正常增殖状态，无腺囊性增生迹象。黄体中期活检显示，A组、B组和C组的分泌期子宫内膜分别适合18.6±1.8天、21.8±1.8天和18.6±1.5天，腺-间质差异不显著。我们得出结论，在卵母细胞捐赠计划中，人工延长卵泡期似乎不会对子宫内膜准备产生不利影响。
