酷似脑膜瘤的颅内细胞淋巴瘤：病例报告以了解复杂的遗传、放射学和组织病理学实体
Intracranial Cell Lymphomas That Mimic Meningiomas: Case Report To Understand Complex Genetic, Radiologic, and Histopathologic Entities.
作者信息
Comes Pierre-Cyril, André Arthur, Nguyen-Khac Florence, Carpentier Alexandre, Bielle Franck, Amelot Aymeric
机构信息
Department of Neurosurgery, La Pitié-Salpétrière Hospital, Paris, France.
Department of Haematology, La Pitié-Salpétrière Hospital, Sorbonne University, APHP, Paris, France.
出版信息
World Neurosurg. 2019 May;125:339-342. doi: 10.1016/j.wneu.2019.01.298. Epub 2019 Feb 22.
BACKGROUND
We describe a patient affected by a T-cell primary central nervous system lymphoma (PCNSL) with highly aberrant specific B-cell markers (CD79a and CD20). An unusual imaging presentation leads us to misdiagnose this lesion for a meningioma and perform surgical resection.
CASE DESCRIPTION
We think that this infrequent anatomic presentation might be due to the aberrant specific B-cell markers (CD79a and CD20) genotype expression. We believe this case to be relevant in order to appreciate the diagnosis of cerebral lymphomas according to various presentations. We wonder whether it was not the aberrant genotype that contributed to this quirky presentation and ultimately if surgery in PCNSL should not be discussed?
CONCLUSIONS
Furthermore, this case calls attention to the complexity of lineage assignment, imaging diagnosis, and treatment strategy in PCNSL.
背景
我们描述了一名患有T细胞原发性中枢神经系统淋巴瘤（PCNSL）的患者，其具有高度异常的特异性B细胞标志物（CD79a和CD20）。一种不寻常的影像学表现导致我们将此病变误诊为脑膜瘤并进行了手术切除。
病例描述
我们认为这种罕见的解剖学表现可能归因于异常的特异性B细胞标志物（CD79a和CD20）基因型表达。我们认为该病例对于根据各种表现来认识脑淋巴瘤的诊断具有重要意义。我们想知道是否不是异常基因型导致了这种奇特的表现，以及最终是否不应讨论PCNSL的手术治疗？
结论
此外，该病例提醒人们注意PCNSL中线系归属、影像学诊断和治疗策略的复杂性。
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