纳米颗粒技术与干细胞疗法联手对抗神经退行性疾病。
Nanoparticle technology and stem cell therapy team up against neurodegenerative disorders.
机构信息
The Biochemistry, Cellular and Molecular Biology Graduate Program, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Department of Neuroscience and Mahoney Institute for Neurosciences, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA; The Institute for Regenerative Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
出版信息
Adv Drug Deliv Rev. 2019 Aug;148:239-251. doi: 10.1016/j.addr.2019.02.007. Epub 2019 Feb 21.
The convergence of nanoparticles and stem cell therapy holds great promise for the study, diagnosis, and treatment of neurodegenerative disorders. Researchers aim to harness the power of nanoparticles to regulate cellular microenvironment, improve the efficiency of cell and drug delivery to the brain, and enhance the survival of stem cell transplants. Understanding the various properties of different nanoparticles is key to applying them to clinical therapies; the many distinct types of nanoparticles offer unique capacities for medical imaging, diagnosis, and treatment of neurodegeneration disorders. In this review we introduce the biology of Alzheimer's, Parkinson's Disease, and amyotrophic lateral sclerosis, and discuss the potentials and shortcomings of metal, silica, lipid-based, polymeric, and hydrogel nanoparticles for diagnosis and treatment of neurodegenerative disorders. We then provide an overview of current strategies in stem cell therapies and how they can be combined with nanotechnology to improve clinical outcomes.
纳米粒子与干细胞疗法的结合为神经退行性疾病的研究、诊断和治疗带来了巨大的希望。研究人员旨在利用纳米粒子的力量来调节细胞微环境，提高细胞和药物向大脑输送的效率，并增强干细胞移植的存活率。了解不同纳米粒子的各种特性是将其应用于临床治疗的关键；许多不同类型的纳米粒子为神经退行性疾病的医学成像、诊断和治疗提供了独特的能力。在这篇综述中，我们介绍了阿尔茨海默病、帕金森病和肌萎缩侧索硬化症的生物学，并讨论了金属、硅、脂质基、聚合物和水凝胶纳米粒子在神经退行性疾病的诊断和治疗方面的潜力和局限性。然后，我们概述了干细胞疗法的当前策略以及如何将其与纳米技术结合以改善临床结果。
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