Faculty of Pharmacy, Department of Pharmaceutical Technology, Hacettepe University, 06100 Ankara, Turkey.
Pharm Res. 2013 Oct;30(10):2499-511. doi: 10.1007/s11095-013-1156-7.
Neurodegenerative disorders are becoming prevalent with the increasing age of the general population. A number of difficulties have emerged for the potential treatment of neurodegenerative diseases, as these disorders may be multi systemic in nature. Due to limitations regarding the blood brain barrier (BBB) structure, efflux pumps and metabolic enzyme expression, conventional drug delivery systems do not provide efficient therapy for neurodegenerative disorders. Nanotechnology can offer impressive improvement of the neurodegenerative disease treatment by using bio-engineered systems interacting with biological systems at a molecular level. This review focuses on the nano-enabled system applications for the treatment and diagnosis of neurodegenerative diseases, in particular Alzheimer’s, Parkinson’s and Prion diseases.
神经退行性疾病随着人口老龄化的加剧变得越来越普遍。由于血脑屏障 (BBB) 结构、外排泵和代谢酶表达的限制，传统的药物输送系统不能为神经退行性疾病提供有效的治疗。纳米技术可以通过使用与生物系统在分子水平上相互作用的生物工程系统，为神经退行性疾病的治疗提供显著的改善。本文综述了纳米技术在治疗和诊断神经退行性疾病，特别是阿尔茨海默病、帕金森病和朊病毒病方面的应用。
