Kosmidis P A, Axelrod A R, Palacas C, Stahl M
Cancer. 1978 Aug;42(2):447-52. doi: 10.1002/1097-0142(197808)42:2<447::aid-cncr2820420211>3.0.co;2-l.
The case of a 49-year-old man with the diagnosis of angioimmunoblastic lymphadenopathy is reported. The patient survived a stormy clinical course. The corticosteroids improved dramatically the clinical picture although the patient developed a staphylococcal septicemia. Before treatment immunological studies were done including quantitation of B and T-cells, antigen stimulation of lymphocytes in vitro, skin tests and skin window. Impairment of cell mediated immunity, decreased T-lymphocytes and increased B-lymphocytes were found. A decreased migration of lymphocytes in the skin window was also found compatible with immunosuppression. A possible presumptive pathogenetic mechanism is described although the cause of this recently described entity remains unknown.
报告了一例诊断为血管免疫母细胞性淋巴结病的49岁男性病例。该患者经历了一段波折的临床病程后存活下来。尽管患者发生了葡萄球菌败血症，但皮质类固醇显著改善了临床症状。在治疗前进行了免疫学研究，包括B细胞和T细胞定量、淋巴细胞体外抗原刺激、皮肤试验和皮肤窗试验。发现细胞介导免疫受损、T淋巴细胞减少和B淋巴细胞增加。还发现皮肤窗试验中淋巴细胞迁移减少，这与免疫抑制相符。尽管这种最近描述的疾病的病因尚不清楚，但描述了一种可能的推测性发病机制。
