NIHR Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust & University of Nottingham, UK; Biology Department, Faculty of Science, University of Sulaimani, Iraq.
NIHR Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust & University of Nottingham, UK.
Virology. 2019 Apr;530:99-106. doi: 10.1016/j.virol.2019.02.002. Epub 2019 Feb 12.
Hepatocellular carcinoma (HCC) is an uncommon but significant outcome of chronic hepatitis C virus (HCV) infection. A serum biomarker for predicting progression to HCC would have a major impact on patient monitoring and clinical management. We explored circulating liver-expressed lectins, ficolin-2, ficolin-3 and mannose binding lectin (MBL), as potential biomarkers for the development of HCC. The activity of these three lectins were analysed in HCV positive patients who developed HCC (n = 31) with comparable HCV-positive HCC-negative patients (n = 106) and healthy controls (n = 79). Serum binding activity of ficolin-2 and MBL were elevated compared to controls. Analysis of pre-HCC onset samples revealed that MBL levels were significantly elevated up to 3 years, and ficolin-2 was elevated up to 1 year, prior to diagnosis of HCC over controls. This preliminary study identifies MBL and ficolin-2 as potential biomarkers for the development of HCC in chronic HCV infection.
肝细胞癌（HCC）是慢性丙型肝炎病毒（HCV）感染的罕见但重要的后果。预测 HCC 进展的血清生物标志物将对患者监测和临床管理产生重大影响。我们探索了循环肝脏表达的凝集素、ficolin-2、ficolin-3 和甘露糖结合凝集素（MBL），作为 HCC 发展的潜在生物标志物。分析了发生 HCC（n=31）的 HCV 阳性患者与可比的 HCV 阳性 HCC 阴性患者（n=106）和健康对照（n=79）中这三种凝集素的活性。ficolin-2 和 MBL 的血清结合活性与对照组相比升高。对 HCC 发病前样本的分析表明，MBL 水平在 HCC 诊断前 3 年内显著升高，ficolin-2 在 HCC 诊断前 1 年内升高，与对照组相比。这项初步研究确定 MBL 和 ficolin-2 是慢性 HCV 感染中 HCC 发展的潜在生物标志物。
