Expression of lipid-protein gene PLP2 in Liaoning cashmere goat.

The relationship between gene and cashmere fiber quality of Liaoning cashmere goat was investigated. The sheep fibroblast cells were treated with exogenous cytokines and melatonin, independently, and RNA interference, RT-PCR and hybridization were utilized for investigating the gene regulation mechanism underlying the Liaoning cashmere growth. The results showed that the expression of gene in the prosperous and degenerative stage is higher than that of the primary follicle, indicating that the gene promotes the secondary follicle, wherein the gene is expressed only in the inner root sheath, suggesting its correlation to hair loss. The results of RT-PCR showed that the trend of FGF5 expression in gene was positively regulated. The influence of MT on the expression of gene was negatively regulated, and the inhibition was gradually enhanced with the passage of time. Studies have confirmed that the Noggin gene is an inhibitor of the BMP signaling pathway. After the noggin gene interferes with the lentivirus infection, the expression of the gene is downregulated. Therefore, the gene, along with the other suppressor genes including the noggin gene, might affect the development of hair follicles by inhibiting the BMP（Bone morphogenetic proteins）pathway.