College of Animal Science, Inner Mongolia Agricultural University, Hohhot, China.
Northern Agriculture and Livestock Husbandry Technical Innovation Center, Chinese Academy of Agricultural Sciences, Hohhot, China.
Front Endocrinol (Lausanne). 2024 Apr 2;15:1361100. doi: 10.3389/fendo.2024.1361100. eCollection 2024.
Melatonin can treat androgenetic alopecia in males. Goats can be used as animal models to study melatonin treatment for human alopecia. In this study, a meta-analysis of melatonin's effects on goat hair follicles was pursued.
Literature from the last 20 years was searched in Scopus, Science Direct, Web of Science and PubMed. Melatonin's effect on goat hair follicles and litter size were performed through a traditional meta-analysis and trial sequential analysis. A network meta-analysis used data from oocyte development to blastocyst. The hair follicle genes regulated by melatonin performed KEGG and PPI. We hypothesized that there are differences in melatonin receptors between different goats, and therefore completed melatonin receptor 1A homology modelling and molecular docking.
The results showed that melatonin did not affect goat primary follicle or litter size. However, there was a positive correlation with secondary follicle growth. The goat SNPs influence melatonin's functioning. The wild type gene defect is a very valuable animal model.
Future studies should focus on the relationship between goat SNPs and the effect of embedded melatonin. This study will provide theoretical guidance for the cashmere industry and will be informative for human alopecia research.
褪黑素可治疗男性雄激素性脱发。山羊可作为动物模型，研究褪黑素治疗人类脱发。本研究对褪黑素对山羊毛囊的影响进行了荟萃分析。
在 Scopus、Science Direct、Web of Science 和 PubMed 中检索了过去 20 年的文献。通过传统的荟萃分析和试验序贯分析，研究了褪黑素对山羊毛囊和产羔数的影响。网络荟萃分析使用卵母细胞发育到囊胚的数据。受褪黑素调节的毛囊基因进行了 KEGG 和 PPI 分析。我们假设不同山羊之间褪黑素受体存在差异，因此完成了褪黑素受体 1A 同源建模和分子对接。
结果表明，褪黑素对山羊初级毛囊或产羔数没有影响。然而，与次级毛囊生长呈正相关。山羊 SNP 影响褪黑素的功能。野生型基因缺陷是一种非常有价值的动物模型。
未来的研究应集中在山羊 SNP 与嵌入褪黑素作用之间的关系上。本研究将为羊绒产业提供理论指导，为人类脱发研究提供信息。
