Laboratory of Endometrium, Endometriosis & Reproductive Medicine, Department Development & Regeneration, KU Leuven, G-PURE, Leuven, Belgium; Laboratory of Ion Channel Research, Department of Cellular and Molecular Medicine, KU Leuven, VIB Centre for Brain & Disease Research, Leuven, Belgium.
Laboratory of Endometrium, Endometriosis & Reproductive Medicine, Department Development & Regeneration, KU Leuven, G-PURE, Leuven, Belgium.
Biochim Biophys Acta Mol Cell Res. 2018 Nov;1865(11 Pt B):1815-1829. doi: 10.1016/j.bbamcr.2018.08.005. Epub 2018 Aug 9.
Calcium plays a key role in many different steps of the reproduction process, from germ cell maturation to placental development. However, the exact function and regulation of calcium throughout subsequent reproductive events remains rather enigmatic. Successful pregnancy requires the establishment of a complex dialogue between the implanting embryo and the endometrium. On the one hand, endometrial cell will undergo massive changes to support an implanting embryo, including stromal cell decidualization. On the other hand, trophoblast cells from the trophectoderm surrounding the inner cell mass will differentiate and acquire new functions such as hormone secretion, invasion and migration. The need for calcium in the different gestational processes implicates the presence of specialized ion channels to regulate calcium homeostasis. The superfamily of transient receptor potential (TRP) channels is a class of calcium permeable ion channels that is involved in the transformation of extracellular stimuli into the influx of calcium, inducing and coordinating underlying signaling pathways. Although the necessity of calcium throughout reproduction cannot be negated, the expression and functionality of TRP channels throughout gestation remains elusive. This review provides an overview of the current evidence regarding the expression and function of TRP channels in reproduction.
钙在生殖过程的许多不同步骤中都起着关键作用，从生殖细胞成熟到胎盘发育。然而，钙在随后的生殖事件中的具体功能和调节仍然相当神秘。成功的妊娠需要植入胚胎和子宫内膜之间建立复杂的对话。一方面，子宫内膜细胞将发生巨大变化以支持植入的胚胎，包括基质细胞蜕膜化。另一方面，来自内细胞团周围的滋养外胚层的滋养细胞将分化并获得新的功能，如激素分泌、侵袭和迁移。不同妊娠过程中对钙的需求暗示存在专门的离子通道来调节钙稳态。瞬时受体电位 (TRP) 通道超家族是一类钙通透离子通道，它参与将细胞外刺激转化为钙内流，诱导和协调潜在的信号通路。尽管钙在生殖过程中的必要性不可否认，但 TRP 通道在整个妊娠过程中的表达和功能仍然难以捉摸。本文综述了关于 TRP 通道在生殖中的表达和功能的现有证据。
