Department of Small Animal Internal Medicine II, School of Veterinary Medicine, Kitasato University, Aomori, Japan.
Faculty of Pharmacy, Kindai University, Osaka, Japan.
J Vet Med Sci. 2023 Dec 6;85(12):1257-1260. doi: 10.1292/jvms.23-0347. Epub 2023 Oct 24.
This study investigated the preventive effect of 5-aminolevulinic acid combined with sodium ferrous citrate (5-ALA/SFC) on blood-aqueous barrier (BAB) breakdown induced after anterior chamber paracentesis (ACP) in beagles. 5-ALA/SFC (1/0.64 mg/kg or 3/1.92 mg/kg) or carprofen (4.0 mg/kg) was orally administered daily for 7 days prior to ACP. Then, a sample of the aqueous humor (AH) was collected from one eye via ACP (first sample) and again 60 min later (second sample). The protein and prostaglandin E2 (PGE2) concentrations in both samples were measured. Compared with the control group, high-dose 5-ALA/SFC and carprofen significantly reduced the AH protein and PGE2 concentrations in the second sample. Our findings suggest that 5-ALA/SFC suppresses BAB breakdown in dogs.
本研究探讨了 5-氨基酮戊酸联合柠檬酸亚铁钠（5-ALA/SFC）对犬眼前房穿刺（ACP）后血房水屏障（BAB）破裂的预防作用。5-ALA/SFC（1/0.64mg/kg 或 3/1.92mg/kg）或卡洛芬（4.0mg/kg）在 ACP 前每日口服给药 7 天。然后，通过 ACP 从一只眼采集房水样品（第一份样品），60 分钟后再次采集（第二份样品）。测量两份样品中的蛋白质和前列腺素 E2（PGE2）浓度。与对照组相比，高剂量 5-ALA/SFC 和卡洛芬显著降低了第二份样品中的 AH 蛋白和 PGE2 浓度。我们的研究结果表明，5-ALA/SFC 可抑制犬的 BAB 破裂。
