Tanaka Yasuyuki, Hirata Daizen, Fujii Shigehiko, Kusaka Toshihiro, Shibuya Shinsuke
Department of Gastroenterology and Hepatology, Kyoto Katsura Hospital, Japan.
Department of Pathology, Kyoto Katsura Hospital, Japan.
Intern Med. 2019 Jun 15;58(12):1727-1731. doi: 10.2169/internalmedicine.2151-18. Epub 2019 Feb 25.
An 80-year-old man was found to have a reddish depressed lesion on the middle thoracic esophagus. The morphology of the lesion had been almost unchanged for 3 years, but it transformed to a 2-cm depressed lesion with elevated margins and an irregular nodular surface. The lesion was resected endoscopically and ultimately diagnosed as a combined neuroendocrine carcinoma and squamous cell carcinoma with submucosal invasion. The patient was additionally treated with chemoradiotherapy but died of the primary disease eight months after the initial treatment. It is important to elucidate the natural history of this disease at an early stage.
一名80岁男性被发现中胸段食管有一个微红的凹陷性病变。该病变的形态3年来几乎未变，但后来转变为一个2厘米的凹陷性病变，边缘隆起，表面有不规则结节。该病变通过内镜切除，最终诊断为合并神经内分泌癌和鳞状细胞癌并伴有黏膜下浸润。患者还接受了放化疗，但在初始治疗8个月后死于原发性疾病。早期阐明这种疾病的自然史很重要。
