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短期内出现显著形态学改变的浅表性食管神经内分泌癌

Superficial Esophageal Neuroendocrine Carcinoma with Marked Morphological Changes in a Short Period.

作者信息

Tanabe Mizuki, Saito Masahiro, Uno Kaname, Koike Tomoyuki, Sato Chiaki, Hatta Waku, Asano Naoki, Fujishima Fumiyoshi, Kamei Takashi, Masamune Atsushi

机构信息

Division of Gastroenterology, Tohoku University Graduate School of Medicine, Japan.

Department of Surgery, Tohoku University Graduate School of Medicine, Japan.

出版信息

Intern Med. 2025 Jun 1;64(11):1666-1672. doi: 10.2169/internalmedicine.4344-24. Epub 2024 Nov 1.

DOI:10.2169/internalmedicine.4344-24
PMID:39496452
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12222931/
Abstract

A de novo whitish subepithelial lesion (SEL) with irregular vascular hyperplasia was detected in the lower thoracic esophagus during endoscopic surveillance. Special types of esophageal cancer were suspected; however, endoscopic biopsy specimens were inadequate for a diagnosis. Ten days later, endoscopic ultrasound showed a 7-mm homogeneously hypoechoic round mass in the submucosa, and a biopsy confirmed a histological diagnosis of esophageal neuroendocrine carcinoma (eNEC). Based on the clinical diagnosis of cT2N0M0, subtotal esophagectomy followed by adjuvant chemotherapy was performed immediately after endoscopic reexamination revealing a 20-mm reddish SEL. We herein report the marked changes in endoscopic findings of eNEC within 1.5 months.

摘要

在内镜监测过程中，在下段胸段食管发现了一个新出现的白色上皮下病变（SEL），伴有不规则血管增生。怀疑为特殊类型的食管癌；然而，内镜活检标本不足以做出诊断。十天后，内镜超声显示黏膜下层有一个7毫米的均匀低回声圆形肿块，活检证实为食管神经内分泌癌（eNEC）的组织学诊断。根据cT2N0M0的临床诊断，在内镜复查发现一个20毫米的红色SEL后，立即进行了次全食管切除术并辅助化疗。我们在此报告eNEC在1.5个月内内镜表现的显著变化。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7532/12222931/40bdef0f44b5/1349-7235-64-11-1666-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7532/12222931/d4e2f7a3e6d5/1349-7235-64-11-1666-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7532/12222931/b16cb84c9e60/1349-7235-64-11-1666-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7532/12222931/cc416aa61a33/1349-7235-64-11-1666-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7532/12222931/d4e694383c50/1349-7235-64-11-1666-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7532/12222931/1e070643044f/1349-7235-64-11-1666-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7532/12222931/60168310a840/1349-7235-64-11-1666-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7532/12222931/40bdef0f44b5/1349-7235-64-11-1666-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7532/12222931/d4e2f7a3e6d5/1349-7235-64-11-1666-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7532/12222931/b16cb84c9e60/1349-7235-64-11-1666-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7532/12222931/cc416aa61a33/1349-7235-64-11-1666-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7532/12222931/d4e694383c50/1349-7235-64-11-1666-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7532/12222931/1e070643044f/1349-7235-64-11-1666-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7532/12222931/60168310a840/1349-7235-64-11-1666-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7532/12222931/40bdef0f44b5/1349-7235-64-11-1666-g007.jpg

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Clinical usefulness of Somatostatin Receptor Scintigraphy in the Diagnosis of Neuroendocrine Neoplasms.生长抑素受体闪烁扫描术在神经内分泌肿瘤诊断中的临床应用价值
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A case of endoscopic submucosal dissection for neuroendocrine carcinoma of the esophagus with invasion to the muscularis mucosae.
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Clin J Gastroenterol. 2022 Apr;15(2):339-344. doi: 10.1007/s12328-022-01595-8. Epub 2022 Jan 24.
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