Mino-León Dolores, Hernández-Carvajal Ixzel, Peredo-Silva Luis, Búrbano-Martínez Gabriel
Instituto Mexicano del Seguro Social, Centro Médico Nacional Siglo XXI, Hospital de Especialidades, Unidad de Investigación en Epidemiología Clínica, Ciudad de México.
Universidad Autónoma de Morelos, Cuernavaca, Morelos.
Gac Med Mex. 2019;155(1):15-19. doi: 10.24875/GMM.18004407.
The relevance of medications for health depends on their quality, accessibility and appropriate use.
To determine the potential therapeutic value of antibiotics that are not included in the World Health Organization Essential Medicines List (EML) but that are part of the National Essential Medicines List (NEML) of the Mexican Ministry of Health, and categorize them according to their intrinsic value.
Descriptive analysis of antibiotics not included in the 2013 World Health Organization EML; literature review to obtain efficacy and safety evidence; and application of quality and intrinsic value scales.
Four hundred and fifty-two abstracts were identified for 19 antibiotics; 56.9 % were excluded; 195 clinical trials were reviewed in full-text articles, out of which 37.9 % were of good quality, and intrinsic value was determined; 54 % were superiority studies, whereas 46 % were non-inferiority or equivalence studies; 32 % of the antibiotics were classified without intrinsic value and nearly 50 % were inconclusive.
An elevated proportion of antibiotics of the NEML had uncertain or no intrinsic value, which favors their inappropriate use, bacterial resistance and puts the population at risk.
药物对健康的相关性取决于其质量、可及性和合理使用。
确定未列入世界卫生组织基本药物清单（EML）但属于墨西哥卫生部国家基本药物清单（NEML）的抗生素的潜在治疗价值，并根据其内在价值进行分类。
对未列入2013年世界卫生组织EML的抗生素进行描述性分析；进行文献综述以获取疗效和安全性证据；应用质量和内在价值量表。
确定了19种抗生素的452篇摘要；56.9%被排除；对195篇全文文章中的临床试验进行了综述，其中37.9%质量良好，并确定了内在价值；54%为优效性研究，46%为非劣效性或等效性研究；32%的抗生素被归类为无内在价值，近50%不确定。
NEML中抗生素比例升高，其内在价值不确定或无内在价值，这助长了其不合理使用、细菌耐药性，并使人群面临风险。
