Shim C, Williams M H
Am J Med. 1986 Jan;80(1):18-22. doi: 10.1016/0002-9343(86)90043-4.
Many patients complain that some odors worsen their asthma. Perfume and cologne are two of the most frequently mentioned offenders. Four patients with a history of worsening of asthma on exposure to cologne underwent challenge with a cologne, and their pulmonary function was tested before, during, and after the exposure. Forced expiratory volume in one second declined 18 to 58 percent below the baseline period during the 10-minute exposure and gradually increased in the next 20 minutes. Saline placebo pretreatment did not affect the response to subsequent challenge. Single-blind pretreatment with metaproterenol and atropine prevented decline in one-second forced expiratory volume in three of four patients and blunted the response in the other. Cromolyn sodium prevented decline in one of four, and occlusion of nostrils prevented decline in one of three. A survey of 60 asthmatic patients revealed a history of respiratory symptoms in 57 on exposure to one or more common odors. Odors are an important cause of worsening of asthma.
许多患者抱怨某些气味会加重他们的哮喘。香水和古龙水是最常被提及的引发因素中的两种。四名有接触古龙水后哮喘加重病史的患者接受了古龙水激发试验，并在接触前、接触期间和接触后对他们的肺功能进行了测试。在10分钟的接触期间，一秒用力呼气量比基线期下降了18%至58%，并在接下来的20分钟内逐渐增加。盐水安慰剂预处理不影响对后续激发试验的反应。用间羟异丙肾上腺素和阿托品进行单盲预处理可防止四名患者中的三名一秒用力呼气量下降，并使另一名患者的反应减弱。色甘酸钠可防止四名患者中的一名下降，堵住鼻孔可防止三名患者中的一名下降。对60名哮喘患者的调查显示，57名患者在接触一种或多种常见气味时有呼吸道症状史。气味是哮喘加重的一个重要原因。
