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N-甲基-D-天冬氨酸受体在阿尔茨海默病中的作用。

The Role of NMDA Receptors in Alzheimer's Disease.

作者信息

Liu Jinping, Chang Lirong, Song Yizhi, Li Hui, Wu Yan

机构信息

School of Medicine, Tsinghua University, Beijing, China.

Department of Anatomy, Ministry of Science and Technology Laboratory of Brain Disorders, Beijing Institute for Brain Disorders, Capital Medical University, Beijing, China.

出版信息

Front Neurosci. 2019 Feb 8;13:43. doi: 10.3389/fnins.2019.00043. eCollection 2019.

DOI:10.3389/fnins.2019.00043
PMID:30800052
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6375899/
Abstract

In Alzheimer's disease (AD), early synaptic dysfunction is associated with the increased oligomeric amyloid-beta peptide, which causes NMDAR-dependent synaptic depression and spine elimination. Memantine, low-affinity NMDAR channel blocker, has been used in the treatment of moderate to severe AD. However, clear evidence is still deficient in demonstrating the underlying mechanisms and a relationship between NMDARs dysfunction and AD. This review focuses on not only changes in expression of different NMDAR subunits, but also some unconventional modes of NMDAR action.

摘要

在阿尔茨海默病（AD）中，早期突触功能障碍与寡聚淀粉样β肽增加有关，该肽会导致NMDAR依赖的突触抑制和树突棘消除。美金刚是一种低亲和力的NMDAR通道阻滞剂，已用于治疗中度至重度AD。然而，在证明其潜在机制以及NMDAR功能障碍与AD之间的关系方面，仍缺乏明确的证据。本综述不仅关注不同NMDAR亚基表达的变化，还关注NMDAR作用的一些非常规模式。

相似文献

[1]
The Role of NMDA Receptors in Alzheimer's Disease.

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[2]
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[3]
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[4]
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[5]
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[6]
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[7]
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[8]
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[9]
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[10]
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本文引用的文献

[1]
Questions concerning the role of amyloid-β in the definition, aetiology and diagnosis of Alzheimer's disease.

Acta Neuropathol. 2018-10-22

[2]
Whole brain imaging reveals distinct spatial patterns of amyloid beta deposition in three mouse models of Alzheimer's disease.

J Comp Neurol. 2018-12-4

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N-methyl-D-aspartate receptor-mediated calcium influx connects amyloid-β oligomers to ectopic neuronal cell cycle reentry in Alzheimer's disease.

Alzheimers Dement. 2018-7-4

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Imaging the evolution and pathophysiology of Alzheimer disease.

Nat Rev Neurosci. 2018-11

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Aβ and the dementia syndrome: Simple versus complex perspectives.

Eur J Clin Invest. 2018-10-4

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-Methyl-D-Aspartate Receptor Link to the MAP Kinase Pathway in Cortical and Hippocampal Neurons and Microglia Is Dependent on Calcium Sensors and Is Blocked by α-Synuclein, Tau, and Phospho-Tau in Non-transgenic and Transgenic APP Mice.

Front Mol Neurosci. 2018-8-28

[7]
Triheteromeric GluN1/GluN2A/GluN2C NMDARs with Unique Single-Channel Properties Are the Dominant Receptor Population in Cerebellar Granule Cells.

Neuron. 2018-6-28

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Glutamate and Glycine Binding to the NMDA Receptor.

Structure. 2018-6-7

[9]
Separate functional properties of NMDARs regulate distinct aspects of spatial cognition.

Learn Mem. 2018-5-15

[10]
Mechanism of NMDA receptor channel block by MK-801 and memantine.

Nature. 2018-4-18

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