一项评估 Jacquemontia pentantha 中植物化合物群体感应抑制能力的多学科研究
A Multidisciplinary Study to Evaluate the Anti-quorum Sensing Ability of Phyto-compounds in Jacq.
作者信息
Chemmugil P, Lakshmi Ptv, Annamalai A
机构信息
Centre for Bioinformatics, Pondicherry University, Pondicherry, India.
PG and Research Department of Botany, Arignar Anna Government College, Thiruvalluvar University, Villupuram, Tamilnadu, India.
出版信息
Avicenna J Med Biotechnol. 2019 Jan-Mar;11(1):48-58.
BACKGROUND
() causing numerous diseases in humans, have become resistant to antibiotics, hence, urging the need for alternative medicines.
METHODS
In this study, the Indian medicinal weed, ) extracted and fractioned through column chromatography was subjected to antibacterial and anti-quorum sensing activity against and Methicillin Resistant Staphylococcus aureus (MRSA).
RESULTS
The obtained results confirmed fraction F44 to have significant effect as antimicrobial and anti-biofilm agent against both the micro-organism. Therefore, few of such highly active fractions were chemical finger printed using GC-MS and the compounds identified were further docked with DNA binding (LytTR) domain of agrA, which revealed that compounds identified from fraction were interactive to the protein.
CONCLUSION
is promising antimicrobial and anti-biofilm agent against and MRSA.
背景
（）在人类中引发多种疾病，已对抗生素产生耐药性，因此迫切需要替代药物。
方法
在本研究中，对印度药用杂草（）进行提取并通过柱色谱法分离，然后针对（）和耐甲氧西林金黄色葡萄球菌（MRSA）进行抗菌和群体感应抑制活性测试。
结果
所得结果证实馏分F44作为针对这两种微生物的抗菌和抗生物膜剂具有显著效果。因此，使用气相色谱 - 质谱联用仪（GC-MS）对少数此类高活性馏分进行化学指纹图谱分析，并将鉴定出的化合物与agrA的DNA结合（LytTR）结构域进行进一步对接，结果表明从馏分中鉴定出的化合物与该蛋白质具有相互作用。
结论
（）是一种有前景的针对（）和MRSA的抗菌和抗生物膜剂。
Zotero 插件