Department of Life Sciences, Imperial College London, London, UK.
Sci Adv. 2019 Feb 20;5(2):eaau9253. doi: 10.1126/sciadv.aau9253. eCollection 2019 Feb.
Sleep appears to be a universally conserved phenomenon among the animal kingdom, but whether this notable evolutionary conservation underlies a basic vital function is still an open question. Using a machine learning-based video-tracking technology, we conducted a detailed high-throughput analysis of sleep in the fruit fly , coupled with a lifelong chronic and specific sleep restriction. Our results show that some wild-type flies are virtually sleepless in baseline conditions and that complete, forced sleep restriction is not necessarily a lethal treatment in wild-type . We also show that circadian drive, and not homeostatic regulation, is the main contributor to sleep pressure in flies. These results offer a new perspective on the biological role of sleep in and, potentially, in other species.
睡眠似乎是动物王国中普遍存在的现象，但这种显著的进化保守性是否是基本生命功能的基础，仍然是一个悬而未决的问题。我们使用基于机器学习的视频跟踪技术，对果蝇的睡眠进行了详细的高通量分析，并结合了终生慢性和特定的睡眠限制。我们的结果表明，一些野生型果蝇在基线条件下几乎没有睡眠，而且完全强制的睡眠限制在野生型中不一定是致命的处理方法。我们还表明，昼夜驱动，而不是稳态调节，是果蝇睡眠压力的主要贡献者。这些结果为睡眠在 和 中的生物学作用提供了一个新的视角，可能也为其他物种提供了一个新的视角。
