Yang David C, Chen Ching-Hsien
Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine and Center for Comparative Respiratory Biology and Medicine, University of California Davis, Davis, California, USA.
Division of Nephrology, Department of Internal Medicine, University of California Davis, Davis, California, USA.
J Nat Sci. 2018 Nov;4(11).
Macrophages, the mature form of the monocytes, play a significant role in tissue homeostasis and immunity. In response to environmental cues, they can undergo classical or alternative activation, polarizing into specialized functional subsets. A common hallmark of the pathologic environment is represented by cigarette smoking. Although the contribution of cigarette smoke to various cellular processes has been extensively studied, its roles in macrophage polarization have been conflicting. This review discusses the molecular and functional differences of cigarette smoke-exposed macrophages that exist between pro-inflammatory and anti-inflammatory states. We also highlight the most recent advances in therapeutic potential of targeting signaling molecules associated with smoking to modulate macrophage plasticity and polarized activation.
巨噬细胞是单核细胞的成熟形式，在组织稳态和免疫中发挥重要作用。响应环境信号，它们可经历经典激活或替代激活，分化为特定的功能亚群。病理环境的一个共同特征是吸烟。尽管香烟烟雾对各种细胞过程的影响已得到广泛研究，但其在巨噬细胞极化中的作用一直存在争议。本文综述了暴露于香烟烟雾的巨噬细胞在促炎和抗炎状态下的分子和功能差异。我们还重点介绍了靶向与吸烟相关的信号分子以调节巨噬细胞可塑性和极化激活的治疗潜力的最新进展。
