Pawlikowski Brad, Wragge Jacob, Siegenthaler Julie A
Department of Molecular, Cell and Developmental Biology, University of Colorado-Boulder, Boulder, Colorado.
Department of Pediatrics-Section of Developmental Biology, University of Colorado, School of Medicine-Anschutz Medical Campus, Aurora, Colorado.
Genesis. 2019 Jul;57(7-8):e23287. doi: 10.1002/dvg.23287. Epub 2019 Mar 19.
Formation of the vasculature is an essential developmental process, delivering oxygen and nutrients to support cellular processes needed for tissue growth and maturation. Retinoic acid (RA) and its downstream signaling pathway is vital for normal pre- and post-natal development, playing key roles in the specification and formation of many organs and tissues. Here, we review the role of RA in blood and lymph vascular development, beginning with embryonic yolk sac vasculogenesis and remodeling and discussing RA's organ-specific roles in angiogenesis and vessel maturation. In particular, we highlight the multi-faceted role of RA signaling in CNS vascular development and acquisition of blood-brain barrier properties.
血管形成是一个必不可少的发育过程，它输送氧气和营养物质以支持组织生长和成熟所需的细胞过程。视黄酸（RA）及其下游信号通路对正常的产前和产后发育至关重要，在许多器官和组织的特化和形成中发挥关键作用。在这里，我们回顾了RA在血液和淋巴管发育中的作用，从胚胎卵黄囊血管生成和重塑开始，并讨论RA在血管生成和血管成熟中的器官特异性作用。特别是，我们强调了RA信号在中枢神经系统血管发育和血脑屏障特性获得中的多方面作用。
