Quan Li-Qiu, Su Li-Hua, Qi Shi-Gang, Xue Yong, Yang Tao, Liu Dan, Zhao Xu-Dong, Li Rong-Tao, Li Hong-Mei
Faculty of Environmental Science and Engineering, Kunming University of Science and Technology, Kunming, 650500, P. R. China.
Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, 650500, P. R. China.
Chem Biodivers. 2019 May;16(5):e1800474. doi: 10.1002/cbdv.201800474. Epub 2019 Apr 8.
Twelve 3,8-epoxy iridoids, including four new compounds, jatamanins R-U (1-4), and eight known compounds (5-12), were obtained from the roots and rhizomes of Valeriana jatamansi. The structures were elucidated from analysis of spectroscopic data. The absolute configurations of 1-4 were determined by comparison of experimental and literature ECD spectra. Moreover, the compounds were evaluated for cytotoxic effects against glioma stem cells, inhibition of NO production, activity against influenza A virus and reversal of multidrug resistance of HepG2/ADR cells. Compounds 9 and 12 showed significant cytotoxic potency against GSC-18# (IC =1.351 and 4.439 μg ml , respectively) and GSC-3# (IC =10.88 and 6.348 μg ml , respectively) glioma stem cells, while compound 12 was also slightly less potent against GSC-12# (IC =13.45 μg ml ) glioma stem cell growth. In addition, compounds 9 and 12 displayed obvious inhibition of NO production (IC =4.6 and 15.8 μm, respectively).
从蜘蛛香的根和根茎中获得了12种3,8-环氧环烯醚萜，包括4个新化合物蜘蛛香素R-U（1-4）和8个已知化合物（5-12）。通过光谱数据分析阐明了其结构。通过比较实验和文献ECD光谱确定了1-4的绝对构型。此外，评估了这些化合物对胶质瘤干细胞的细胞毒性作用、对一氧化氮产生的抑制作用、对甲型流感病毒的活性以及对HepG2/ADR细胞多药耐药性的逆转作用。化合物9和12对GSC-18#（IC分别为1.351和4.439μg·ml）和GSC-3#（IC分别为10.88和6.348μg·ml）胶质瘤干细胞显示出显著的细胞毒性效力，而化合物12对GSC-12#（IC =13.45μg·ml）胶质瘤干细胞生长的效力也略低。此外，化合物9和12对一氧化氮的产生表现出明显的抑制作用（IC分别为4.6和15.8μm）。
