缬草中的环烯醚萜和双环烯醚萜及其对人神经胶质瘤干细胞的细胞毒性。
Iridoids and bis-iridoids from Valeriana jatamansi and their cytotoxicity against human glioma stem cells.
机构信息
Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, 650500, Yunnan, PR China.
The First Department of Neurosurgery, The Second Affiliated Hospital, Kunming Medical University, Kunming, 650101, Yunnan, PR China; Zoology Department, Faculty of Science, Minia University, Minia, 61519, Egypt.
出版信息
Phytochemistry. 2020 Jul;175:112372. doi: 10.1016/j.phytochem.2020.112372. Epub 2020 Apr 16.
An undescribed iridoid (valeridoid A) and five undescribed bis-iridoids (valeridoids B-F), along with four known ones, were isolated from the roots and rhizomes of Valeriana jatamansi. Their structures were elucidated based on 1D and 2D NMR, as well as HRESIMS spectroscopic data. In addition, 8,9-didehydro-7-hydroxydolichodial and valeridoid F were found to inhibit the growth of three human glioma stem cells (GSC-3#, GSC-12# and GSC-18#).
从缬草中分离得到一种未知的环烯醚萜（缬草 A）和五种未知的双环烯醚萜（缬草 B-F），以及四种已知的化合物。根据 1D 和 2D NMR 以及 HRESIMS 光谱数据阐明了它们的结构。此外，8,9-去氢-7-羟基厚藤素和缬草 F 被发现抑制三种人神经胶质瘤干细胞（GSC-3#、GSC-12#和 GSC-18#）的生长。
Zotero 插件