Versnel M A, van Dongen J J, Geurts van Kessel A H, de Klein A, Bos N A, Hagemeijer A
Cancer Genet Cytogenet. 1986 Jan 15;19(3-4):321-30. doi: 10.1016/0165-4608(86)90061-0.
A newly isolated Burkitt lymphoma cell line, ROS-1, carrying the specific translocation (8;14) has been studied using somatic cell hybridization techniques. As in other reported Burkitt cell lines, the oncogene c-myc was found to be translocated from the 8q- to the 14q+ chromosome. In contrast to other reports, expression of the mu immunoglobulin (Ig) heavy chain correlated with the presence of the 14q+ derivative and not of its normal homologue. These results indicate that the translocation (8;14) is not necessarily an abortive event for the production of the mu Ig heavy chain by the 14q+ derivative.
利用体细胞杂交技术对新分离出的携带特异性易位（8；14）的伯基特淋巴瘤细胞系ROS-1进行了研究。与其他报道的伯基特细胞系一样，癌基因c-myc被发现从8号染色体长臂（8q-）易位至14号染色体长臂（14q+）。与其他报道不同的是，μ免疫球蛋白（Ig）重链的表达与14q+衍生染色体的存在相关，而非与其正常同源染色体相关。这些结果表明，（8；14）易位不一定是14q+衍生染色体产生μ Ig重链的失败事件。
