Kharseeva G G, Voronina N A, Gasretova T D, Tyukavkina S Yu, Sylka O I, Mironov A Yu
The Rostovskii state medical university, 344022, Rostov-on-Don, Russia.
The G.N. Gabrichevskii Moscow research institute of epidemiology and microbiology of Rospotrebnadzor, 125212, Moscow, Russia.
Klin Lab Diagn. 2017;62(8):502-506. doi: 10.18821/0869-2084-2017-62-8-502-506.
The purpose of study is to analyze sensitivity of various species Corynebacterium non diphtheriaе to antibacterial pharmaceuticals. The strains of C. non diphtheriae are separated from patients with pathology of respiratory and urogenital tract and also from individuals subjected to preventive examination. The sensitivity to antibacterial pharmaceuticals was determined using technique of serial dilution in fluid growth medium on the basis values of minimal inhibitory concentration (mg per l). It is established that the most efficient antibacterial pharmaceuticals in the case of strains C. non diphtheriae proved to be Vancomycin, Cefazolin and Cefotaxime in general. In case of such particular species as С. pseudodiphtheriticum -- Cefazolin, Cefotaxime and Gentamycin; С.pseudotuberculosis -- Vancomycin, Cefazolin, Cefotaxime and Gentamycin; C. xerosis -- Cefotaxime; С.striatum -- Cefazolin and и Rifampicin. The least efficiency was manifested for strains C. non diphtheriae by Benzylpenicillin and Lincomycin in general. In case of such particular species as С. pseudodiphtheriticum and С. pseudotuberculosis -- Lincomycin and Erythromycin; C. xerosis and С. striatum -- Benzylpenicillin, Lincomycin and Erythromycin. In case of various species of C. non diphtheriae Сephalosporins (Cefotaxime and Cefazolin) can be recommended as pharmaceuticals of choice and Gentamycin and Vancomycin as reserve pharmaceuticals.
本研究的目的是分析各种非结核分枝杆菌对抗菌药物的敏感性。非结核分枝杆菌菌株从患有呼吸道和泌尿生殖道疾病的患者以及接受预防性检查的个体中分离得到。基于最低抑菌浓度（毫克/升）的值，采用液体生长培养基中的连续稀释技术测定对抗菌药物的敏感性。结果表明，对于非结核分枝杆菌菌株，最有效的抗菌药物总体上是万古霉素、头孢唑林和头孢噻肟。对于诸如假结核分枝杆菌等特定菌种，有效的抗菌药物是头孢唑林、头孢噻肟和庆大霉素；假结核棒状杆菌——万古霉素、头孢唑林、头孢噻肟和庆大霉素；干燥棒状杆菌——头孢噻肟；纹带棒状杆菌——头孢唑林和利福平。总体而言，非结核分枝杆菌菌株对苄青霉素和林可霉素的效果最差。对于诸如假结核分枝杆菌和假结核棒状杆菌等特定菌种，效果最差的是林可霉素和红霉素；干燥棒状杆菌和纹带棒状杆菌——苄青霉素、林可霉素和红霉素。对于各种非结核分枝杆菌菌种，头孢菌素（头孢噻肟和头孢唑林）可作为首选药物推荐，庆大霉素和万古霉素作为备用药物。
