加拿大因纽特人中的群体特异性成分、α1-抗胰蛋白酶和酯酶D。

Group-specific component, alpha1-antitrypsin and esterase D in Canadian Eskimos.

作者信息

Cox D W, Simpson N E, Jantti R

出版信息

Hum Hered. 1978;28(5):341-50. doi: 10.1159/000152976.

Abstract

Three genetic markers - group-specific component (Gc), alpha1-antitrypsin, and esterase D - were examined in a population of Eskimos from Igloolik in the eastern Canadian Arctic. Gc and esterase D were found to be polymorphic. In addition to the common Gc types, an anodal variant called Gc Igloolik was found, probably identical to previously reported Gc Eskimo. Gene frequencies were Gc1: 0.6524, Gc2: 0.3373, GcIgl: 0.0104, for 338 Eskimos. Genetic types of alpha1-antitrypsin (Pi types) were mostly M, with two MS sibs who were half Caucasian, in 170 Eskimos. Frequencies of the esterase D allele in 336 Eskimos were EsD1: 0.7083, EsD2: 0.2917. The frequencies of Gc2 and EsD2 are both higher than are found in Caucasian populations.

摘要

在加拿大北极地区东部伊格卢利克的爱斯基摩人群体中，对三种遗传标记——群特异性成分（Gc）、α1-抗胰蛋白酶和酯酶D进行了检测。发现Gc和酯酶D具有多态性。除了常见的Gc类型外，还发现了一种名为Gc伊格卢利克的阳极变体，可能与先前报道的爱斯基摩Gc相同。对338名爱斯基摩人而言，基因频率为：Gc1：0.6524，Gc2：0.3373，GcIgl：0.0104。在170名爱斯基摩人中，α1-抗胰蛋白酶的遗传类型（Pi类型）大多为M型，有两名MS型同胞，他们有一半高加索人血统。在336名爱斯基摩人中，酯酶D等位基因的频率为：EsD1：0.7083，EsD2：0.2917。Gc2和EsD2的频率均高于高加索人群体中的频率。