加拿大梅蒂斯人的α1-抗胰蛋白酶表型
Alpha 1-antitrypsin phenotypes in Canadian Metis.
作者信息
Singh R, Horne S L, Gerrard J W, DeCoteau W E
出版信息
Hum Hered. 1983;33(3):181-3. doi: 10.1159/000153372.
PMID:6603408
Abstract
Alpha 1-antitrypsin phenotyping was performed on serum of 344 Metis living in an isolated northern Saskatchewan community. Only PiM and PiMZ phenotypes were observed with phenotype frequencies of 98.5 and 1.5 respectively. Gene frequencies were 0.993 for PiM and 0.007 for PiZ. The low frequency of non-M phenotypes is similar to that in another population of North American natives, the Eskimos of Igloolik as well as Finnish and Norwegian Lapps.
摘要
对生活在萨斯喀彻温省北部一个与世隔绝社区的344名梅蒂斯人的血清进行了α1-抗胰蛋白酶表型分析。仅观察到PiM和PiMZ表型，其表型频率分别为98.5%和1.5%。PiM的基因频率为0.993，PiZ的基因频率为0.007。非M表型的低频率与北美原住民的另一群体——伊格卢利克的爱斯基摩人以及芬兰和挪威的拉普人相似。
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