使用诱导多能干细胞研究肝胆发育和肝脏疾病的人类相关临床前体外模型。
Human-relevant preclinical in vitro models for studying hepatobiliary development and liver diseases using induced pluripotent stem cells.
机构信息
1 Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD 21205, USA.
2 Cellular and Molecular Medicine Graduate Program, Baltimore, MD 21205, USA.
出版信息
Exp Biol Med (Maywood). 2019 May;244(8):702-708. doi: 10.1177/1535370219834895. Epub 2019 Feb 26.
Abstract
In this review, we address the potential of human-induced pluripotent stem cell-based hepatobiliary differentiation technology as a means to study human liver development and cell fate determination, and to model liver diseases in an effort to develop a new human-relevant preclinical platform for drug development.
摘要
在这篇综述中，我们探讨了基于人诱导多能干细胞的肝胆分化技术作为一种研究人类肝脏发育和细胞命运决定的手段的潜力，并探讨了该技术在建模肝脏疾病方面的应用，以期为药物开发建立一个新的具有人类相关性的临床前平台。
相似文献
1
Human-relevant preclinical in vitro models for studying hepatobiliary development and liver diseases using induced pluripotent stem cells.使用诱导多能干细胞研究肝胆发育和肝脏疾病的人类相关临床前体外模型。
Exp Biol Med (Maywood). 2019 May;244(8):702-708. doi: 10.1177/1535370219834895. Epub 2019 Feb 26.
2
Establishment of human induced pluripotent stem cell-derived hepatobiliary organoid with bile duct for pharmaceutical research use.建立人诱导多能干细胞衍生的具有胆管的肝胆管类器官，用于药物研究用途。
Biomaterials. 2024 Oct;310:122621. doi: 10.1016/j.biomaterials.2024.122621. Epub 2024 May 22.
3
Human hepatocytes derived from pluripotent stem cells: a promising cell model for drug hepatotoxicity screening.源自多能干细胞的人肝细胞：一种用于药物肝毒性筛选的有前景的细胞模型。
Arch Toxicol. 2016 Sep;90(9):2049-2061. doi: 10.1007/s00204-016-1756-1. Epub 2016 Jun 20.
4
Stem-cell derived hepatocyte-like cells for the assessment of drug-induced liver injury.用于评估药物性肝损伤的干细胞衍生肝样细胞
Differentiation. 2019 Mar-Apr;106:15-22. doi: 10.1016/j.diff.2019.02.004. Epub 2019 Feb 19.
5
High-Fidelity Drug-Induced Liver Injury Screen Using Human Pluripotent Stem Cell-Derived Organoids.使用人多能干细胞衍生类器官进行高逼真度药物性肝损伤筛选。
Gastroenterology. 2021 Feb;160(3):831-846.e10. doi: 10.1053/j.gastro.2020.10.002. Epub 2020 Oct 8.
6
Efficient and Controlled Generation of 2D and 3D Bile Duct Tissue from Human Pluripotent Stem Cell-Derived Spheroids.高效且可控地从人多能干细胞衍生的球体生成 2D 和 3D 胆管组织。
Stem Cell Rev Rep. 2016 Aug;12(4):500-8. doi: 10.1007/s12015-016-9657-5.
7
Generation of expandable human pluripotent stem cell-derived hepatocyte-like liver organoids.扩增型人多能干细胞来源的肝样类器官的生成。
J Hepatol. 2019 Nov;71(5):970-985. doi: 10.1016/j.jhep.2019.06.030. Epub 2019 Jul 9.
8
PRC1 catalytic unit RING1B regulates early neural differentiation of human pluripotent stem cells.PRC1 催化单元 RING1B 调节人多能干细胞的早期神经分化。
Exp Cell Res. 2020 Nov 1;396(1):112294. doi: 10.1016/j.yexcr.2020.112294. Epub 2020 Sep 21.
9
Feeder-free and serum-free production of hepatocytes, cholangiocytes, and their proliferating progenitors from human pluripotent stem cells: application to liver-specific functional and cytotoxic assays.从人多能干细胞中无饲养层和无血清培养肝细胞、胆管细胞及其增殖祖细胞：在肝脏特异性功能和细胞毒性检测中的应用
Cell Reprogram. 2012 Apr;14(2):171-85. doi: 10.1089/cell.2011.0064. Epub 2012 Mar 2.
10
Generation of hepatobiliary organoids from human induced pluripotent stem cells.从人诱导多能干细胞生成肝胆类器官。
J Hepatol. 2019 Jun;70(6):1145-1158. doi: 10.1016/j.jhep.2018.12.028. Epub 2019 Jan 7.
引用本文的文献
1
A comparison of hepato-cellular in vitro platforms to study CYP3A4 induction.肝细胞体外模型比较用于研究 CYP3A4 诱导。
PLoS One. 2020 Feb 27;15(2):e0229106. doi: 10.1371/journal.pone.0229106. eCollection 2020.
本文引用的文献
1
Transient c-Src Suppression During Endodermal Commitment of Human Induced Pluripotent Stem Cells Results in Abnormal Profibrotic Cholangiocyte-Like Cells.人诱导多能干细胞内胚层定向分化过程中短暂的 c-Src 抑制导致异常成纤维细胞样胆小管细胞。
Stem Cells. 2019 Mar;37(3):306-317. doi: 10.1002/stem.2950. Epub 2018 Dec 17.
2
Biliary Atresia Relevant Human Induced Pluripotent Stem Cells Recapitulate Key Disease Features in a Dish.先天性胆道闭锁相关的人诱导多能干细胞在体外重现疾病关键特征。
J Pediatr Gastroenterol Nutr. 2019 Jan;68(1):56-63. doi: 10.1097/MPG.0000000000002187.
3
Bioengineered Liver Models for Drug Testing and Cell Differentiation Studies.用于药物测试和细胞分化研究的生物工程肝脏模型
Cell Mol Gastroenterol Hepatol. 2017 Dec 6;5(3):426-439.e1. doi: 10.1016/j.jcmgh.2017.11.012. eCollection 2018 Mar.
4
Derivation of a disease-specific human induced pluripotent stem cell line from a biliary atresia patient.从一名胆道闭锁患者中获得疾病特异性人类诱导多能干细胞系。
Stem Cell Res. 2017 Oct;24:25-28. doi: 10.1016/j.scr.2017.08.001. Epub 2017 Aug 8.
5
Emerging concepts in biliary repair and fibrosis.胆道修复与纤维化的新观念
Am J Physiol Gastrointest Liver Physiol. 2017 Aug 1;313(2):G102-G116. doi: 10.1152/ajpgi.00452.2016. Epub 2017 May 19.
6
Patient-specific hepatocyte-like cells derived from induced pluripotent stem cells model pazopanib-mediated hepatotoxicity.诱导多能干细胞来源的患者特异性肝细胞样细胞模型用于评价帕唑帕尼所致肝毒性。
Sci Rep. 2017 Jan 25;7:41238. doi: 10.1038/srep41238.
7
Hippo Signaling in the Liver Regulates Organ Size, Cell Fate, and Carcinogenesis.肝脏中的河马信号通路调控器官大小、细胞命运和癌症发生。
Gastroenterology. 2017 Feb;152(3):533-545. doi: 10.1053/j.gastro.2016.10.047. Epub 2016 Dec 19.
8
Alcohol Increases Liver Progenitor Populations and Induces Disease Phenotypes in Human IPSC-Derived Mature Stage Hepatic Cells.酒精增加人类诱导多能干细胞衍生的成熟阶段肝细胞中的肝祖细胞群体并诱导疾病表型。
Int J Biol Sci. 2016 Jul 18;12(9):1052-62. doi: 10.7150/ijbs.15811. eCollection 2016.
9
LATS-YAP/TAZ controls lineage specification by regulating TGFβ signaling and Hnf4α expression during liver development.LATS-YAP/TAZ 通过调节 TGFβ 信号和 Hnf4α 表达在肝发育过程中控制谱系特化。
Nat Commun. 2016 Jun 30;7:11961. doi: 10.1038/ncomms11961.
10
Gene correction in patient-specific iPSCs for therapy development and disease modeling.用于治疗开发和疾病建模的患者特异性诱导多能干细胞中的基因校正。
Hum Genet. 2016 Sep;135(9):1041-58. doi: 10.1007/s00439-016-1691-5. Epub 2016 Jun 2.
Zotero 插件