瘦素缺乏的绝经后女性乳腺癌可能具有特定的病理特征。
Breast Cancer in Lean Postmenopausal Women Might Have Specific Pathological Features.
作者信息
Uomori Toshitaka, Horimoto Yoshiya, Arakawa Atsushi, Iijima Kotaro, Saito Mitsue
机构信息
Deartment of Breast Oncology, Juntendo University School of Medcine, Tokyo, Japan.
Deartment of Breast Oncology, Juntendo University School of Medcine, Tokyo, Japan
出版信息
In Vivo. 2019 Mar-Apr;33(2):483-487. doi: 10.21873/invivo.11499.
BACKGROUND/AIM: The rate of obesity, an independent risk factor for breast cancer in post-menopausal women, is quite low in Japan, indicating breast cancer in lean women to be more common in the Japanese than in Westerners. However, biological characteristics of such breast cancers have not been adequately investigated.
PATIENTS AND METHODS
We retrospectively investigated clinicopathological breast cancer features of 566 postmenopausal Japanese women, who underwent curative surgery, in relation to patient physique based on the body mass index.
RESULTS
There were no differences in several factors examined such as tumour size according to patient physique. On the other hand, mean values of the Ki67 labelling index were significantly higher in lean compared to obese patients (p=0.027). Likewise, HER2-positive tumours were more often observed in lean patients (p=0.051).
CONCLUSION
Lean postmenopausal women had more aggressive tumours, apparently contradicting the widely held view for breast cancer in obese women.
背景/目的：肥胖是绝经后女性患乳腺癌的一个独立风险因素，在日本肥胖率相当低，这表明在日本瘦女性患乳腺癌比西方人更常见。然而，此类乳腺癌的生物学特性尚未得到充分研究。
患者与方法
我们回顾性调查了566名接受根治性手术的绝经后日本女性的临床病理特征，这些特征与基于体重指数的患者体格有关。
结果
根据患者体格，在诸如肿瘤大小等几个检查因素方面没有差异。另一方面，与肥胖患者相比，瘦患者的Ki67标记指数平均值显著更高（p = 0.027）。同样，瘦患者中更常观察到HER2阳性肿瘤（p = 0.051）。
结论
绝经后瘦女性的肿瘤更具侵袭性，这显然与肥胖女性患乳腺癌的普遍观点相矛盾。
Zotero 插件