碳离子放疗在特殊脂肪肉瘤治疗中的应用：一例报告
Carbon Ion Radiotherapy in the Management of Unusual Liposarcomas: A Case Report.
作者信息
Vitolo Viviana, Barcellini Amelia, Fossati Piero, Fiore Maria Rosaria, Vischioni Barbara, Iannalfi Alberto, Facoetti Angelica, Bonora Maria, Ronchi Sara, D'Ippolito Emma, Petrucci Rachele, Viselner Gisela, Preda Lorenzo, Ciocca Mario, Valvo Francesca, Orecchia Roberto
机构信息
National Center of Oncological Hadrontherapy (Fondazione CNAO), Pavia, Italy.
National Center of Oncological Hadrontherapy (Fondazione CNAO), Pavia, Italy
出版信息
In Vivo. 2019 Mar-Apr;33(2):529-533. doi: 10.21873/invivo.11506.
BACKGROUND
Liposarcomas are the most common soft-tissue sarcomas in adulthood. Orbital and spermatic cord liposarcomas are uncommon and there is no consensus on their management. The treatment of choice is wide excision, which may be destructive and lead to unacceptable morbidity. When surgery is declined by patients and in recurrent disease, management can be challenging. We report two cases of liposarcoma treated with carbon ion radiotherapy at the National Center for Oncological Hadrontherapy (Fondazione CNAO) in Italy.
CASE REPORT
A woman with orbital liposarcoma and a man with spermatic cord liposarcoma were referred to our Center and accepted for carbon ion radiotherapy. The treatment was well tolerated and late toxicities were mild. Good local control was achieved in patients.
CONCLUSION
In our experience, carbon ion radiotherapy is an effective and safe option, especially in cases of tumor at high risk for local relapse, in patients with multiple local recurrences, and in patients who refuse destructive surgery.
背景
脂肪肉瘤是成人中最常见的软组织肉瘤。眼眶和精索脂肪肉瘤并不常见，其治疗方法尚无共识。首选治疗方法是广泛切除，这可能具有破坏性并导致不可接受的发病率。当患者拒绝手术以及疾病复发时，治疗可能具有挑战性。我们报告了两例在意大利国家肿瘤强子治疗中心（CNAO基金会）接受碳离子放疗的脂肪肉瘤病例。
病例报告
一名患有眼眶脂肪肉瘤的女性和一名患有精索脂肪肉瘤的男性被转诊至我们中心并接受了碳离子放疗。治疗耐受性良好，晚期毒性轻微。患者实现了良好的局部控制。
结论
根据我们的经验，碳离子放疗是一种有效且安全的选择，特别是对于局部复发风险高的肿瘤病例、有多处局部复发的患者以及拒绝进行破坏性手术的患者。
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