Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.
Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.
Cell Mol Immunol. 2019 Jul;16(7):627-633. doi: 10.1038/s41423-019-0211-7. Epub 2019 Feb 25.
Innate lymphocytes are a diverse population of cells that carry out specialized functions in steady-state homeostasis and during immune challenge. While circulating cytotoxic natural killer (NK) cells have been studied for decades, tissue-resident innate lymphoid cells (ILCs) have only been characterized and studied over the past few years. As ILCs have been largely viewed in the context of helper T-cell biology, models of ILC lineage and function have been founded within this perspective. Notably, tissue-resident innate lymphocytes with cytotoxic potential have been described in an array of tissues, yet whether they are derived from the NK or ILC lineage is only beginning to be elucidated. In this review, we aim to shed light on the identities of innate lymphocytes through the lenses of cell lineage, localization, and timing of differentiation.
天然淋巴细胞是一个多样化的细胞群体，它们在稳态平衡和免疫挑战期间执行专门的功能。虽然循环细胞毒性自然杀伤 (NK) 细胞已经研究了几十年，但组织驻留天然淋巴细胞 (ILC) 仅在过去几年才得到描述和研究。由于 ILC 主要在辅助 T 细胞生物学的背景下进行研究，因此 ILC 谱系和功能的模型是在此基础上建立的。值得注意的是，已经在多种组织中描述了具有细胞毒性潜力的组织驻留天然淋巴细胞，但它们是否来自 NK 或 ILC 谱系才刚刚开始被阐明。在这篇综述中，我们旨在通过细胞谱系、定位和分化时间的视角来揭示天然淋巴细胞的特性。
