Huang Yuefeng, Mao Kairui, Chen Xi, Sun Ming-An, Kawabe Takeshi, Li Weizhe, Usher Nicholas, Zhu Jinfang, Urban Joseph F, Paul William E, Germain Ronald N
Laboratory of Immunology, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health, Bethesda, MD 20892, USA.
Laboratory of Systems Biology, NIAID, National Institutes of Health, Bethesda, MD 20892, USA.
Science. 2018 Jan 5;359(6371):114-119. doi: 10.1126/science.aam5809.
Innate lymphoid cells (ILCs) are innate counterparts of adaptive T lymphocytes, contributing to host defense, tissue repair, metabolic homeostasis, and inflammatory diseases. ILCs have been considered to be tissue-resident cells, but whether ILCs move between tissue sites during infection has been unclear. We show here that interleukin-25- or helminth-induced inflammatory ILC2s are circulating cells that arise from resting ILC2s residing in intestinal lamina propria. They migrate to diverse tissues based on sphingosine 1-phosphate (S1P)-mediated chemotaxis that promotes lymphatic entry, blood circulation, and accumulation in peripheral sites, including the lung, where they contribute to anti-helminth defense and tissue repair. This ILC2 expansion and migration is a behavioral parallel to the antigen-driven proliferation and migration of adaptive lymphocytes to effector sites and indicates that ILCs complement adaptive immunity by providing both local and distant tissue protection during infection.
固有淋巴细胞（ILCs）是适应性T淋巴细胞的固有对应物，有助于宿主防御、组织修复、代谢稳态和炎症性疾病。ILCs一直被认为是组织驻留细胞，但在感染期间ILCs是否在组织部位之间移动尚不清楚。我们在此表明，白细胞介素-25或蠕虫诱导的炎性ILC2s是循环细胞，它们源自存在于肠道固有层的静止ILC2s。它们基于1-磷酸鞘氨醇（S1P）介导的趋化作用迁移到不同组织，这种趋化作用促进淋巴进入、血液循环以及在包括肺在内的外周部位积累，在肺中它们有助于抗蠕虫防御和组织修复。这种ILC2的扩增和迁移在行为上类似于适应性淋巴细胞对抗原驱动的增殖和向效应部位的迁移，表明ILCs通过在感染期间提供局部和远距离组织保护来补充适应性免疫。
