Gad-Elkareem Mohamed A M, Abdelgadir Elkhatim H, Badawy Ossama M, Kadri Adel
Department of Chemistry, Faculty of Science and Arts in Baljurashi, Albaha University, Albaha, Saudi Arabia.
Chemistry Department, Faculty of Science, Al-Azhar University, Assiut, Egypt.
PeerJ. 2019 Feb 18;7:e6441. doi: 10.7717/peerj.6441. eCollection 2019.
Recently, herbal drugs and their bioactive compounds have gained popularity in the management of diabetes mellitus (DM), which has become an epidemic disease all over the world and is especially prevalent in the Kingdom of Saudi Arabia (KSA). This study aimed to investigate the antidiabetic effect of ethanolic and aqueous-ethanolic extracts of wild () leaves in streptozotocin (STZ) induced diabetic rats. Diabetic rats were administered orally with the mentioned extracts at doses of 300 and 600 mg/kg/BW for 14 days, and the obtained results of different biochemical parameters were compared with normal control, diabetic control and standard drug glibenclamide (5 mg/kg/BW). The obtained results revealed a remarkable and significantly ( < 0.05) reverse effect of the body weight loss, observed when diabetic rats were treated with ethanol and aqueous-ethanol extracts at 300 mg/kg/BW. Administration of the ethanol extract at 600 mg/kg/BW significantly ( < 0.05) reduced the blood glucose level. A significant increase in the AST, ALT and ALP levels ( < 0.05) was observed in the diabetic control and in the experimental groups with glibenclamide which was also significantly ( < 0.05) lowered after treatment with extracts at special doses. Total proteins, albumin, total bilirubin, direct bilirubin, creatinine and urea were also investigated and compared to the corresponding controls. We showed that administration of extract generally significantly ( < 0.05) ameliorated the biochemical parameters of diabetic rats. Also, the changes in serum electrolyte profile were assessed and the results demonstrate that administration of extracts at concentration of 600 mg/kg/BW generally inhibits the alteration maintain their levels. The obtained data imply the hypoglycemic effects of this plant, which may be used as a good alternative for managing DM and therefore validating its traditional usage in KSA.
近年来，草药及其生物活性化合物在糖尿病（DM）的管理中越来越受欢迎，糖尿病已成为一种全球性的流行病，在沙特阿拉伯王国（KSA）尤为普遍。本研究旨在探讨野生（此处原文缺失植物名称）叶的乙醇提取物和水乙醇提取物对链脲佐菌素（STZ）诱导的糖尿病大鼠的抗糖尿病作用。糖尿病大鼠口服上述提取物，剂量为300和600 mg/kg体重，持续14天，并将不同生化参数的所得结果与正常对照、糖尿病对照和标准药物格列本脲（5 mg/kg体重）进行比较。所得结果显示，当糖尿病大鼠用300 mg/kg体重的乙醇和水乙醇提取物治疗时，体重减轻有显著且明显（P<0.05）的逆转作用。以600 mg/kg体重给予乙醇提取物显著（P<0.05）降低了血糖水平。在糖尿病对照组和使用格列本脲的实验组中，AST、ALT和ALP水平显著升高（P<0.05），在用特定剂量的提取物治疗后也显著（P<0.05）降低。还对总蛋白、白蛋白、总胆红素、直接胆红素、肌酐和尿素进行了研究，并与相应对照进行了比较。我们表明，给予（此处原文缺失植物名称）提取物总体上显著（P<0.05）改善了糖尿病大鼠的生化参数。此外，评估了血清电解质谱的变化，结果表明，以600 mg/kg体重的浓度给予提取物通常会抑制变化并维持其水平。所得数据表明该植物具有降血糖作用，可作为管理糖尿病的良好替代品，从而验证其在沙特阿拉伯王国的传统用途。
