Hoang Thi Ngoc Nhon, Nguyen Quang Liem, Le Thi Thanh Ngan, Vo Ngoc Hoa, Dong Thi Anh Dao, Le Thi Hong Anh
Faculty of Food Science and Technology Ho chi Minh City University of Industry and Trade (HUIT) Ho Chi Minh City Vietnam.
Department of Food Technology, Faculty of Chemical Engineering Ho chi Minh City University of Technology (HCMUT) Ho Chi Minh City Vietnam.
Food Sci Nutr. 2024 Nov 7;12(12):10347-10356. doi: 10.1002/fsn3.4573. eCollection 2024 Dec.
Diabetes mellitus is a chronic metabolic disorder that can cause elevated blood glucose levels due to impaired insulin secretion or resistance. Different parts of have been used widely in traditional medicine to treat many disorders. The present study aims to evaluate the antidiabetic ability of the corm, pseudostem, inflorescence, fruit, peel, and seed of via in vitro experiments by inhibiting α-amylase and α-glucosidase enzymes as well as in vivo models on diabetic alloxan-induced mice. The results show that all investigated parts have performed potential inhibition on two investigated digestive enzymes. Seed poses the highest capacity among surveyed parts on α-amylase (IC:f μg/mL) and α-glucosidase (IC: 21.63 μg/mL) as well as effectively lowers the blood glucose index (IG) in alloxan-induced mice. In addition, fruit, corm, and inflorescence are considered essential parts that have high hypoglycemic effects via in vivo experiments. These findings indicate that all parts are possibly a potential source for hypoglycemic agents; further clinical studies are needed to evaluate the safety of human beings before applying them in functional food and pharmaceutical industries.
糖尿病是一种慢性代谢紊乱疾病,由于胰岛素分泌受损或抵抗,可导致血糖水平升高。[植物名称]的不同部位在传统医学中被广泛用于治疗多种疾病。本研究旨在通过体外实验抑制α-淀粉酶和α-葡萄糖苷酶,以及在糖尿病四氧嘧啶诱导的小鼠体内模型中,评估[植物名称]的球茎、假茎、花序、果实、果皮和种子的抗糖尿病能力。结果表明,所有研究部位对两种研究的消化酶均有潜在抑制作用。在所调查的部位中,种子对α-淀粉酶(IC:f μg/mL)和α-葡萄糖苷酶(IC:21.63 μg/mL)的抑制能力最强,并且能有效降低四氧嘧啶诱导的小鼠的血糖指数(IG)。此外,通过体内实验,果实、球茎和花序被认为是具有高降血糖作用的重要部位。这些发现表明,[植物名称]的所有部位都可能是降血糖药物的潜在来源;在将它们应用于功能性食品和制药行业之前,需要进一步的临床研究来评估其对人类的安全性。