Research Division, Institute of Mental Health, 10 Buangkok View, Buangkok Green Medical Park, Singapore, 539747, Singapore.
Centre for Health Services Research and Policy Research, Saw Swee Hock School of Public Health, National University of Singapore, National University Health System, Singapore, Singapore.
Qual Life Res. 2019 Jun;28(6):1509-1520. doi: 10.1007/s11136-019-02126-8. Epub 2019 Feb 25.
Quality of life is an important clinical outcome in individuals with schizophrenia. Illness severity and physical activity (PA) were independently reported to influence health-related quality of life (HRQoL) in people with schizophrenia. This study attempts to examine the intensity and types of PA and their impact on HRQoL, as well as the relative contributions of illness severity, PA, and sedentary behavior (SB) to HRQoL in people with schizophrenia.
Demographic information was collected from 297 community-dwelling individuals with schizophrenia. Severity of illness was assessed on the Clinical Global Impression-Severity (CGI-S); PA and SB were assessed on the Global Physical Activity Questionnaire (GPAQ); HRQoL was assessed on the RAND-36. Regression analyses were conducted to examine the impact of different types and intensities of PA on HRQoL, and the relative impact of CGI-S, GPAQ-PA, and GPAQ-SB on HRQoL.
Most participants had low PA level, and travel is the main type of PA adopted. Leisure time, travel-related, work-related, moderate-, and vigorous-intensity PA were all not associated with HRQoL. Lower severity of illness was significantly associated with better physical (PHC), mental (MHC) and global (GHC) health composites of the RAND-36 (GHC: t = - 5.628, p < 0.001, PHC: t = - 4.026, p < 0.001, MHC: t = - 5.534, p < 0.001). Both PA and SB were not significantly associated with PHC, MHC, and GHC.
Severity of illness has a significant impact on HRQoL in people with schizophrenia. However, we found no evidence to support the association between physical activity and sedentary behavior with HRQoL.
生活质量是精神分裂症患者的一个重要临床结局。已有研究报道，疾病严重程度和身体活动（PA）独立影响精神分裂症患者的健康相关生活质量（HRQoL）。本研究试图探讨 PA 的强度和类型及其对 HRQoL 的影响，以及疾病严重程度、PA 和久坐行为（SB）对精神分裂症患者 HRQoL 的相对贡献。
从 297 名社区居住的精神分裂症患者中收集人口统计学信息。使用临床总体印象严重程度量表（CGI-S）评估疾病严重程度；使用全球体力活动问卷（GPAQ）评估 PA 和 SB；使用 RAND-36 评估 HRQoL。进行回归分析以探讨不同类型和强度的 PA 对 HRQoL 的影响，以及 CGI-S、GPAQ-PA 和 GPAQ-SB 对 HRQoL 的相对影响。
大多数参与者的 PA 水平较低，且主要的 PA 类型是出行。休闲时间、与出行相关、与工作相关、中强度和高强度 PA 均与 HRQoL 无关。疾病严重程度越低，RAND-36 的身体成分（PHC）、心理成分（MHC）和总体健康成分（GHC）越好（GHC：t=-5.628，p<0.001，PHC：t=-4.026，p<0.001，MHC：t=-5.534，p<0.001）。PA 和 SB 与 PHC、MHC 和 GHC 均无显著相关性。
疾病严重程度对精神分裂症患者的 HRQoL 有显著影响。然而，我们没有发现证据支持 PA 和 SB 与 HRQoL 之间存在关联。
