烟酰胺对大鼠肝脏酪氨酸转氨酶（EC 2.5.1.5）的诱导作用（作者译）
[Induction of tyrosine aminotransferase (EC 2.5.1.5) by nicotinamide in rat liver (author's transl)].
作者信息
Kröger H, Grätz R
出版信息
J Clin Chem Clin Biochem. 1978 Sep;16(9):525-9.
PMID:30807
Abstract
In intact rats nicotinamide induces an increase of tyrosine aminotransferase depending on the dose of nicotinamide. In adrenalectomized rats an increase of tyrosine aminotransferase activity is only found up to a dose of 250 mg/kg nicotinamide. The combination of nicotinamide with L-methionine and/or cortisone acetate does not cause a significant increase of the enzyme activity, which, however, can be seen in the presence of L-tyrosine.
摘要
在完整大鼠中，烟酰胺可诱导酪氨酸转氨酶增加，这取决于烟酰胺的剂量。在肾上腺切除的大鼠中，仅在烟酰胺剂量达到250mg/kg时才发现酪氨酸转氨酶活性增加。烟酰胺与L-甲硫氨酸和/或醋酸可的松联合使用不会导致该酶活性显著增加，然而，在L-酪氨酸存在的情况下可以观察到酶活性增加。
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